Cargando…

Warfarin Pharmacogenomics for Precision Medicine in Real-Life Clinical Practice in Southern Africa: Harnessing 73 Variants in 29 Pharmacogenes

Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet needs further development in resource-limited countries. While there is an abundance of genetic association studies in controlled medical settings, there is a paucity of studies with a naturalistic design in real-life...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muyambo, Sarudzai, Ndadza, Arinao, Soko, Nyarai D., Kruger, Bianca, Kadzirange, Gerard, Chimusa, Emile, Masimirembwa, Collen M., Ntsekhe, Mpiko, Nhachi, Charles F.B., Dandara, Collet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792494/ https://www.ncbi.nlm.nih.gov/pubmed/34958284 http://dx.doi.org/10.1089/omi.2021.0199

Ejemplares similares

Profiling of warfarin pharmacokinetics‐associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics‐dosing algorithm
por: Ndadza, Arinao, et al.
Publicado: (2021)

A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics
por: Soko, Nyarai D., et al.
Publicado: (2018)

Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
por: Soko, Nyarai Desiree, et al.
Publicado: (2023)

The COVID-19 Pandemic and Explaining Outcomes in Africa: Could Genomic Variation Add to the Debate?
por: Soko, Nyarai D., et al.
Publicado: (2022)

African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa
por: Dandara, Collet, et al.
Publicado: (2019)

CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe
por: Dhoro, Milcah, et al.
Publicado: (2015)

A cervical cancer biorepository for pharmacogenomics research in Zimbabwe
por: Kuguyo, Oppah, et al.
Publicado: (2022)

Analytical validation of GenoPharm a clinical genotyping open array panel of 46 pharmacogenes inclusive of variants unique to people of African ancestry
por: Kanji, Comfort Ropafadzo, et al.
Publicado: (2023)

Pharmacokinetics of Tamoxifen and Its Major Metabolites and the Effect of the African Ancestry Specific CYP2D6*17 Variant on the Formation of the Active Metabolite, Endoxifen
por: Kanji, Comfort Ropafadzo, et al.
Publicado: (2023)

Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
por: Runcharoen, Chakkaphan, et al.
Publicado: (2021)

In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel
por: Kapungu, Nyasha Nicole, et al.
Publicado: (2020)

Ethnic Diversity and Warfarin Pharmacogenomics
por: Asiimwe, Innocent G., et al.
Publicado: (2022)

Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon
por: Wonkam, Ambroise, et al.
Publicado: (2020)

Pharmacogenomics Guided-Personalization of Warfarin and Tamoxifen
por: Wigle, Theodore J., et al.
Publicado: (2017)

Pharmacovariome scanning using whole pharmacogene resequencing coupled with deep computational analysis and machine learning for clinical pharmacogenomics
por: Tafazoli, Alireza, et al.
Publicado: (2023)

Verification of five pharmacogenomics-based warfarin administration models
por: Lin, Meiqin, et al.
Publicado: (2016)

Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation
por: Warnich, Louise, et al.
Publicado: (2011)

Suprasellar Cysticercosis Cyst with Optic Nerve Compression Masquerading as an Arachnoid Cyst
por: Musara, Aaron, et al.
Publicado: (2019)

The importance of perseverance, pilot studies and the search for effective adjuvant therapies in the management of tuberculous pericarditis
por: Mutyaba, Arthur, et al.
Publicado: (2016)

Is there a role of pharmacogenomics in Africa
por: Matimba, A., et al.
Publicado: (2016)

Pharmacogene regulatory elements: from discovery to applications
por: Smith, Robin P, et al.
Publicado: (2012)

Identification, conservation, and expression of tiered pharmacogenes in zebrafish
por: Demery-Poulos, Catherine, et al.
Publicado: (2022)

Genetic Variation among Pharmacogenes in the Sardinian Population
por: Idda, Maria Laura, et al.
Publicado: (2022)

Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
por: Thomford, Nicholas E., et al.
Publicado: (2015)

Genetic variation in the 3′-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2, and UGT2B7: potential effects on regulation by microRNA and pharmacogenomics relevance
por: Swart, Marelize, et al.
Publicado: (2014)

Novel oral anticoagulants and the 73rd anniversary of historical warfarin
por: Shehab, Abdulla, et al.
Publicado: (2016)

Impact of CYP2C9‐Interacting Drugs on Warfarin Pharmacogenomics
por: Agrawal, Saaket, et al.
Publicado: (2020)

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe
por: Mhandire, Doreen, et al.
Publicado: (2019)

Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir
por: Mutiti, Chenai Sheilla, et al.
Publicado: (2021)

Ontogeny-related pharmacogene changes in the pediatric liver transcriptome
por: Meier, Richard, et al.
Publicado: (2018)

Pharmacogene Variation Consortium Gene Introduction: NUDT15
por: Yang, Jun J., et al.
Publicado: (2018)

Sex-Biased Expression of Pharmacogenes across Human Tissues
por: Idda, Maria Laura, et al.
Publicado: (2021)

Comprehensive characterization of pharmacogenes in a Taiwanese Han population
por: Lu, Hsing-Fang, et al.
Publicado: (2022)

Quantification of spatial pharmacogene expression heterogeneity in breast tumors
por: Powell, Nicholas R., et al.
Publicado: (2022)

Human immunodeficiency virus‐associated heart failure in sub‐Saharan Africa: evolution in the epidemiology, pathophysiology, and clinical manifestations in the antiretroviral era
por: Ntusi, Ntobeko A. B., et al.
Publicado: (2016)

Cervical cancer in Zimbabwe: a situation analysis
por: Kuguyo, Oppah, et al.
Publicado: (2017)

Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study
por: Ntsekhe, Mpiko, et al.
Publicado: (2012)

Learning from biomedical linked data to suggest valid pharmacogenes
por: Dalleau, Kevin, et al.
Publicado: (2017)

Added Value of Clinical Sequencing: WGS-Based Profiling of Pharmacogenes
por: Caspar, Sylvan M., et al.
Publicado: (2020)

Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform
por: Kim, Byungwook, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_49q6pgknd3f7tt6el7l64b000e