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Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection

Since the appearance of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 in China, diabetes mellitus (DM) and hyperglycemia in patients infected with SARS-CoV, represent independent predictors of mortality. Therefore, metabolic control has played a major role in the prognosis of...

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Autores principales: Vargas-Rodriguez, Jose R., Garza-Veloz, Idalia, Flores-Morales, Virginia, Badillo-Almaraz, Jose I., Rocha-Pizaña, Maria R., Valdés-Aguayo, José J., Martinez-Fierro, Margarita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792738/
https://www.ncbi.nlm.nih.gov/pubmed/35096863
http://dx.doi.org/10.3389/fmed.2021.758414
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author Vargas-Rodriguez, Jose R.
Garza-Veloz, Idalia
Flores-Morales, Virginia
Badillo-Almaraz, Jose I.
Rocha-Pizaña, Maria R.
Valdés-Aguayo, José J.
Martinez-Fierro, Margarita L.
author_facet Vargas-Rodriguez, Jose R.
Garza-Veloz, Idalia
Flores-Morales, Virginia
Badillo-Almaraz, Jose I.
Rocha-Pizaña, Maria R.
Valdés-Aguayo, José J.
Martinez-Fierro, Margarita L.
author_sort Vargas-Rodriguez, Jose R.
collection PubMed
description Since the appearance of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 in China, diabetes mellitus (DM) and hyperglycemia in patients infected with SARS-CoV, represent independent predictors of mortality. Therefore, metabolic control has played a major role in the prognosis of these patients. In the current pandemic of coronavirus disease 19 (COVID-19), multiple studies have shown that DM is one of the main comorbidities associated with COVID-19 and higher risk of complications and death. The incidence and prevalence of COVID-19 complications and death related with hyperglycemia in patients with or without DM are high. There are many hypotheses related with worse prognosis and death related to COVID-19 and/or hyperglycemia. However, the information about the interplay between hyperglycemia and angiotensin-converting enzyme 2 (ACE2), the critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the context of SARS-CoV-2 infection, is almost null, but there is enough information to consider the possible participation of hyperglycemia in the glycation of this protein, unleashing a pool of reactions leading to acute respiratory distress syndrome and death in patients with COVID-19. In this document we investigated the current evidence related with ACE2 as a key element within the pathophysiological mechanism related with hyperglycemia extrapolating it to context of SARS-CoV-2 infection and its relationship with worse prognosis and death for COVID-19.
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spelling pubmed-87927382022-01-28 Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection Vargas-Rodriguez, Jose R. Garza-Veloz, Idalia Flores-Morales, Virginia Badillo-Almaraz, Jose I. Rocha-Pizaña, Maria R. Valdés-Aguayo, José J. Martinez-Fierro, Margarita L. Front Med (Lausanne) Medicine Since the appearance of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 in China, diabetes mellitus (DM) and hyperglycemia in patients infected with SARS-CoV, represent independent predictors of mortality. Therefore, metabolic control has played a major role in the prognosis of these patients. In the current pandemic of coronavirus disease 19 (COVID-19), multiple studies have shown that DM is one of the main comorbidities associated with COVID-19 and higher risk of complications and death. The incidence and prevalence of COVID-19 complications and death related with hyperglycemia in patients with or without DM are high. There are many hypotheses related with worse prognosis and death related to COVID-19 and/or hyperglycemia. However, the information about the interplay between hyperglycemia and angiotensin-converting enzyme 2 (ACE2), the critical receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the context of SARS-CoV-2 infection, is almost null, but there is enough information to consider the possible participation of hyperglycemia in the glycation of this protein, unleashing a pool of reactions leading to acute respiratory distress syndrome and death in patients with COVID-19. In this document we investigated the current evidence related with ACE2 as a key element within the pathophysiological mechanism related with hyperglycemia extrapolating it to context of SARS-CoV-2 infection and its relationship with worse prognosis and death for COVID-19. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8792738/ /pubmed/35096863 http://dx.doi.org/10.3389/fmed.2021.758414 Text en Copyright © 2022 Vargas-Rodriguez, Garza-Veloz, Flores-Morales, Badillo-Almaraz, Rocha-Pizaña, Valdés-Aguayo and Martinez-Fierro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Vargas-Rodriguez, Jose R.
Garza-Veloz, Idalia
Flores-Morales, Virginia
Badillo-Almaraz, Jose I.
Rocha-Pizaña, Maria R.
Valdés-Aguayo, José J.
Martinez-Fierro, Margarita L.
Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
title Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
title_full Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
title_fullStr Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
title_full_unstemmed Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
title_short Hyperglycemia and Angiotensin-Converting Enzyme 2 in Pulmonary Function in the Context of SARS-CoV-2 Infection
title_sort hyperglycemia and angiotensin-converting enzyme 2 in pulmonary function in the context of sars-cov-2 infection
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792738/
https://www.ncbi.nlm.nih.gov/pubmed/35096863
http://dx.doi.org/10.3389/fmed.2021.758414
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