Cargando…

Silica Nanoparticles Promote α-Synuclein Aggregation and Parkinson’s Disease Pathology

Silica nanoparticles (SiO(2) NPs) are increasingly investigated for their potential in drug delivery systems. However, the neurotoxicity of SiO(2) NPs remains to be fully clarified. Previously SiO(2) NPs have been reported to be detected in the central nervous system, especially in the dopaminergic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Xin, Yang, Yingxu, Xia, Danhao, Meng, Lanxia, He, Mingyang, Liu, Chaoyang, Zhang, Zhentao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792744/ https://www.ncbi.nlm.nih.gov/pubmed/35095403 http://dx.doi.org/10.3389/fnins.2021.807988

Ejemplares similares

The γ-Adducin 1–357 fragment promotes tau pathology
por: Yu, Honglu, et al.
Publicado: (2023)

The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson’s disease
por: Meng, Lanxia, et al.
Publicado: (2023)

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
por: Dai, Lijun, et al.
Publicado: (2021)

Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson’s Disease
por: Tian, Ye, et al.
Publicado: (2021)

N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity
por: Zhou, Lingyan, et al.
Publicado: (2022)

The Early Events That Initiate β-Amyloid Aggregation in Alzheimer’s Disease
por: Zhang, Xingyu, et al.
Publicado: (2018)

Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
por: Liu, Zhiyong, et al.
Publicado: (2023)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

Dynamics of a model for the degradation mechanism of aggregated α-synuclein in Parkinson's disease
por: Yang, Bojie, et al.
Publicado: (2023)

Tau in the Pathophysiology of Parkinson’s Disease
por: Pan, Lina, et al.
Publicado: (2021)

Injection of α-syn-98 Aggregates Into the Brain Triggers α-Synuclein Pathology and an Inflammatory Response
por: Du, Tingfu, et al.
Publicado: (2019)

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients
por: Piancone, Federica, et al.
Publicado: (2021)

Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease
por: Yan, Mingmin, et al.
Publicado: (2022)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

SUMOylation in α-Synuclein Homeostasis and Pathology
por: Savyon, Mor, et al.
Publicado: (2020)

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
por: Du, Tingting, et al.
Publicado: (2021)

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
por: Schulz-Schaeffer, Walter J.
Publicado: (2010)

The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of α-Synuclein in Parkinson’s Disease
por: Zhang, Fan, et al.
Publicado: (2022)

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
por: Fitzgerald, Emily, et al.
Publicado: (2019)

Anionic Nanoplastic Contaminants Promote Parkinson’s Disease-Associated α-Synuclein Aggregation
por: Liu, Zhiyong, et al.
Publicado: (2023)

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy
por: Xu, Chuan-Ying, et al.
Publicado: (2017)

Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease
por: Bellucci, Arianna, et al.
Publicado: (2020)

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
por: Bridi, Jessika C., et al.
Publicado: (2018)

Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease
por: Canerina-Amaro, Ana, et al.
Publicado: (2019)

Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
por: Vieira, Bruno Di Marco, et al.
Publicado: (2015)

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation
por: Popova, Blagovesta, et al.
Publicado: (2021)

Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation
por: Chlebowicz, Julita, et al.
Publicado: (2023)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
por: Tatenhorst, Lars, et al.
Publicado: (2016)

α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
por: Baena-Montes, Jara M., et al.
Publicado: (2021)

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
por: Smith, Jessica K., et al.
Publicado: (2023)

Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease
por: Hou, Kaiying, et al.
Publicado: (2023)

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
por: Emin, Derya, et al.
Publicado: (2022)

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity
por: Abul Khair, Salema B., et al.
Publicado: (2018)

Effect of L-DOPA/Benserazide on Propagation of Pathological α-Synuclein
por: Shimozawa, Aki, et al.
Publicado: (2019)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
por: Tofaris, George K.
Publicado: (2022)

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
por: Ikenaka, Kensuke, et al.
Publicado: (2019)

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
por: Butkovich, Laura M., et al.
Publicado: (2018)

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
por: Zhang, Jiaming, et al.
Publicado: (2019)

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
por: O’Hara, Darren M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1dg4dl5l70jd5reuv30tu1pn7c