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DNA Damage Repair in Brain Tumor Immunotherapy
With the gradual understanding of tumor development, many tumor therapies have been invented and applied in clinical work, and immunotherapy has been widely concerned as an emerging hot topic in the last decade. It is worth noting that immunotherapy is nowadays applied under too harsh conditions, an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792754/ https://www.ncbi.nlm.nih.gov/pubmed/35095931 http://dx.doi.org/10.3389/fimmu.2021.829268 |
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author | Zhao, Shihong Xu, Boya Ma, Wenbin Chen, Hao Jiang, Chuanlu Cai, Jinquan Meng, Xiangqi |
author_facet | Zhao, Shihong Xu, Boya Ma, Wenbin Chen, Hao Jiang, Chuanlu Cai, Jinquan Meng, Xiangqi |
author_sort | Zhao, Shihong |
collection | PubMed |
description | With the gradual understanding of tumor development, many tumor therapies have been invented and applied in clinical work, and immunotherapy has been widely concerned as an emerging hot topic in the last decade. It is worth noting that immunotherapy is nowadays applied under too harsh conditions, and many tumors are defined as “cold tumors” that are not sensitive to immunotherapy, and brain tumors are typical of them. However, there is much evidence that suggests a link between DNA damage repair mechanisms and immunotherapy. This may be a breakthrough for the application of immunotherapy in brain tumors. Therefore, in this review, first, we will describe the common pathways of DNA damage repair. Second, we will focus on immunotherapy and analyze the mechanisms of DNA damage repair involved in the immune process. Third, we will review biomarkers that have been or may be used to evaluate immunotherapy for brain tumors, such as TAMs, RPA, and other molecules that may provide a precursor assessment for the rational implementation of immunotherapy for brain tumors. Finally, we will discuss the rational combination of immunotherapy with other therapeutic approaches that have an impact on the DNA damage repair process in order to open new pathways for the application of immunotherapy in brain tumors, to maximize the effect of immunotherapy on DNA damage repair mechanisms, and to provide ideas and guidance for immunotherapy in brain tumors. |
format | Online Article Text |
id | pubmed-8792754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87927542022-01-28 DNA Damage Repair in Brain Tumor Immunotherapy Zhao, Shihong Xu, Boya Ma, Wenbin Chen, Hao Jiang, Chuanlu Cai, Jinquan Meng, Xiangqi Front Immunol Immunology With the gradual understanding of tumor development, many tumor therapies have been invented and applied in clinical work, and immunotherapy has been widely concerned as an emerging hot topic in the last decade. It is worth noting that immunotherapy is nowadays applied under too harsh conditions, and many tumors are defined as “cold tumors” that are not sensitive to immunotherapy, and brain tumors are typical of them. However, there is much evidence that suggests a link between DNA damage repair mechanisms and immunotherapy. This may be a breakthrough for the application of immunotherapy in brain tumors. Therefore, in this review, first, we will describe the common pathways of DNA damage repair. Second, we will focus on immunotherapy and analyze the mechanisms of DNA damage repair involved in the immune process. Third, we will review biomarkers that have been or may be used to evaluate immunotherapy for brain tumors, such as TAMs, RPA, and other molecules that may provide a precursor assessment for the rational implementation of immunotherapy for brain tumors. Finally, we will discuss the rational combination of immunotherapy with other therapeutic approaches that have an impact on the DNA damage repair process in order to open new pathways for the application of immunotherapy in brain tumors, to maximize the effect of immunotherapy on DNA damage repair mechanisms, and to provide ideas and guidance for immunotherapy in brain tumors. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8792754/ /pubmed/35095931 http://dx.doi.org/10.3389/fimmu.2021.829268 Text en Copyright © 2022 Zhao, Xu, Ma, Chen, Jiang, Cai and Meng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Shihong Xu, Boya Ma, Wenbin Chen, Hao Jiang, Chuanlu Cai, Jinquan Meng, Xiangqi DNA Damage Repair in Brain Tumor Immunotherapy |
title | DNA Damage Repair in Brain Tumor Immunotherapy |
title_full | DNA Damage Repair in Brain Tumor Immunotherapy |
title_fullStr | DNA Damage Repair in Brain Tumor Immunotherapy |
title_full_unstemmed | DNA Damage Repair in Brain Tumor Immunotherapy |
title_short | DNA Damage Repair in Brain Tumor Immunotherapy |
title_sort | dna damage repair in brain tumor immunotherapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792754/ https://www.ncbi.nlm.nih.gov/pubmed/35095931 http://dx.doi.org/10.3389/fimmu.2021.829268 |
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