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DNA Damage Repair in Brain Tumor Immunotherapy

With the gradual understanding of tumor development, many tumor therapies have been invented and applied in clinical work, and immunotherapy has been widely concerned as an emerging hot topic in the last decade. It is worth noting that immunotherapy is nowadays applied under too harsh conditions, an...

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Autores principales: Zhao, Shihong, Xu, Boya, Ma, Wenbin, Chen, Hao, Jiang, Chuanlu, Cai, Jinquan, Meng, Xiangqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792754/
https://www.ncbi.nlm.nih.gov/pubmed/35095931
http://dx.doi.org/10.3389/fimmu.2021.829268
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author Zhao, Shihong
Xu, Boya
Ma, Wenbin
Chen, Hao
Jiang, Chuanlu
Cai, Jinquan
Meng, Xiangqi
author_facet Zhao, Shihong
Xu, Boya
Ma, Wenbin
Chen, Hao
Jiang, Chuanlu
Cai, Jinquan
Meng, Xiangqi
author_sort Zhao, Shihong
collection PubMed
description With the gradual understanding of tumor development, many tumor therapies have been invented and applied in clinical work, and immunotherapy has been widely concerned as an emerging hot topic in the last decade. It is worth noting that immunotherapy is nowadays applied under too harsh conditions, and many tumors are defined as “cold tumors” that are not sensitive to immunotherapy, and brain tumors are typical of them. However, there is much evidence that suggests a link between DNA damage repair mechanisms and immunotherapy. This may be a breakthrough for the application of immunotherapy in brain tumors. Therefore, in this review, first, we will describe the common pathways of DNA damage repair. Second, we will focus on immunotherapy and analyze the mechanisms of DNA damage repair involved in the immune process. Third, we will review biomarkers that have been or may be used to evaluate immunotherapy for brain tumors, such as TAMs, RPA, and other molecules that may provide a precursor assessment for the rational implementation of immunotherapy for brain tumors. Finally, we will discuss the rational combination of immunotherapy with other therapeutic approaches that have an impact on the DNA damage repair process in order to open new pathways for the application of immunotherapy in brain tumors, to maximize the effect of immunotherapy on DNA damage repair mechanisms, and to provide ideas and guidance for immunotherapy in brain tumors.
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spelling pubmed-87927542022-01-28 DNA Damage Repair in Brain Tumor Immunotherapy Zhao, Shihong Xu, Boya Ma, Wenbin Chen, Hao Jiang, Chuanlu Cai, Jinquan Meng, Xiangqi Front Immunol Immunology With the gradual understanding of tumor development, many tumor therapies have been invented and applied in clinical work, and immunotherapy has been widely concerned as an emerging hot topic in the last decade. It is worth noting that immunotherapy is nowadays applied under too harsh conditions, and many tumors are defined as “cold tumors” that are not sensitive to immunotherapy, and brain tumors are typical of them. However, there is much evidence that suggests a link between DNA damage repair mechanisms and immunotherapy. This may be a breakthrough for the application of immunotherapy in brain tumors. Therefore, in this review, first, we will describe the common pathways of DNA damage repair. Second, we will focus on immunotherapy and analyze the mechanisms of DNA damage repair involved in the immune process. Third, we will review biomarkers that have been or may be used to evaluate immunotherapy for brain tumors, such as TAMs, RPA, and other molecules that may provide a precursor assessment for the rational implementation of immunotherapy for brain tumors. Finally, we will discuss the rational combination of immunotherapy with other therapeutic approaches that have an impact on the DNA damage repair process in order to open new pathways for the application of immunotherapy in brain tumors, to maximize the effect of immunotherapy on DNA damage repair mechanisms, and to provide ideas and guidance for immunotherapy in brain tumors. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8792754/ /pubmed/35095931 http://dx.doi.org/10.3389/fimmu.2021.829268 Text en Copyright © 2022 Zhao, Xu, Ma, Chen, Jiang, Cai and Meng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Shihong
Xu, Boya
Ma, Wenbin
Chen, Hao
Jiang, Chuanlu
Cai, Jinquan
Meng, Xiangqi
DNA Damage Repair in Brain Tumor Immunotherapy
title DNA Damage Repair in Brain Tumor Immunotherapy
title_full DNA Damage Repair in Brain Tumor Immunotherapy
title_fullStr DNA Damage Repair in Brain Tumor Immunotherapy
title_full_unstemmed DNA Damage Repair in Brain Tumor Immunotherapy
title_short DNA Damage Repair in Brain Tumor Immunotherapy
title_sort dna damage repair in brain tumor immunotherapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792754/
https://www.ncbi.nlm.nih.gov/pubmed/35095931
http://dx.doi.org/10.3389/fimmu.2021.829268
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