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A Review on the Role of SPRY4-IT1 in the Carcinogenesis

Sprouty RTK signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is a long non-coding RNA (lncRNA) encoded by a gene located on 5q31.3. This lncRNA has a possible role in the regulation of cell growth, proliferation, and apoptosis. Moreover, since SPRY4-IT1 controls levels of lipin 2, it is also...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Taheri, Mohammad, Shojaei, Seyedpouzhia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792834/
https://www.ncbi.nlm.nih.gov/pubmed/35096580
http://dx.doi.org/10.3389/fonc.2021.779483
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Taheri, Mohammad
Shojaei, Seyedpouzhia
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Taheri, Mohammad
Shojaei, Seyedpouzhia
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Sprouty RTK signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is a long non-coding RNA (lncRNA) encoded by a gene located on 5q31.3. This lncRNA has a possible role in the regulation of cell growth, proliferation, and apoptosis. Moreover, since SPRY4-IT1 controls levels of lipin 2, it is also involved in the biosynthesis of lipids. During the process of biogenesis, SPRY4-IT1 is produced as a primary transcript which is then cleaved to generate a mature transcript which is localized in the cytoplasm. SPRY4-IT1 has oncogenic roles in diverse tissues. A possible route of participation of SPRY4-IT1 in the carcinogenesis is through sequestering miRNAs such as miR-101-3p, miR‐6882‐3p and miR-22-3p. The sponging effect of SPRY4-IT1 on miR-101 has been verified in colorectal cancer, osteosarcoma, cervical cancer, bladder cancer, gastric cancer and cholangiocarcinoma. SPRY4-IT1 has functional interactions with HIF-1α, NF-κB/p65, AMPK, ZEB1, MAPK and PI3K/Akt signaling. We explain the role of SPRY4-IT1 in the carcinogenesis according to evidence obtained from cell lines, xenograft models and clinical studies.
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spelling pubmed-87928342022-01-28 A Review on the Role of SPRY4-IT1 in the Carcinogenesis Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Taheri, Mohammad Shojaei, Seyedpouzhia Front Oncol Oncology Sprouty RTK signaling antagonist 4-intronic transcript 1 (SPRY4-IT1) is a long non-coding RNA (lncRNA) encoded by a gene located on 5q31.3. This lncRNA has a possible role in the regulation of cell growth, proliferation, and apoptosis. Moreover, since SPRY4-IT1 controls levels of lipin 2, it is also involved in the biosynthesis of lipids. During the process of biogenesis, SPRY4-IT1 is produced as a primary transcript which is then cleaved to generate a mature transcript which is localized in the cytoplasm. SPRY4-IT1 has oncogenic roles in diverse tissues. A possible route of participation of SPRY4-IT1 in the carcinogenesis is through sequestering miRNAs such as miR-101-3p, miR‐6882‐3p and miR-22-3p. The sponging effect of SPRY4-IT1 on miR-101 has been verified in colorectal cancer, osteosarcoma, cervical cancer, bladder cancer, gastric cancer and cholangiocarcinoma. SPRY4-IT1 has functional interactions with HIF-1α, NF-κB/p65, AMPK, ZEB1, MAPK and PI3K/Akt signaling. We explain the role of SPRY4-IT1 in the carcinogenesis according to evidence obtained from cell lines, xenograft models and clinical studies. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8792834/ /pubmed/35096580 http://dx.doi.org/10.3389/fonc.2021.779483 Text en Copyright © 2022 Ghafouri-Fard, Khoshbakht, Taheri and Shojaei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Taheri, Mohammad
Shojaei, Seyedpouzhia
A Review on the Role of SPRY4-IT1 in the Carcinogenesis
title A Review on the Role of SPRY4-IT1 in the Carcinogenesis
title_full A Review on the Role of SPRY4-IT1 in the Carcinogenesis
title_fullStr A Review on the Role of SPRY4-IT1 in the Carcinogenesis
title_full_unstemmed A Review on the Role of SPRY4-IT1 in the Carcinogenesis
title_short A Review on the Role of SPRY4-IT1 in the Carcinogenesis
title_sort review on the role of spry4-it1 in the carcinogenesis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792834/
https://www.ncbi.nlm.nih.gov/pubmed/35096580
http://dx.doi.org/10.3389/fonc.2021.779483
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