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Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease

Background: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of...

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Autores principales: Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Lee, Joongyub, Oh, Yun Kyu, Jung, Ji Yong, Lee, Kyu-Beck, Oh, Kook-Hwan, Ma, Seong Kwon, Bae, Eun Hui, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792836/
https://www.ncbi.nlm.nih.gov/pubmed/35097010
http://dx.doi.org/10.3389/fcvm.2021.789488
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author Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Lee, Kyu-Beck
Oh, Kook-Hwan
Ma, Seong Kwon
Bae, Eun Hui
Kim, Soo Wan
author_facet Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Lee, Kyu-Beck
Oh, Kook-Hwan
Ma, Seong Kwon
Bae, Eun Hui
Kim, Soo Wan
author_sort Suh, Sang Heon
collection PubMed
description Background: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of high serum adiponectin level with the risk of adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD. Methods: A total of 1,127 patients with pre-dialysis CKD from a nationwide prospective cohort of patients with pre-dialysis CKD in Korea were divided into the tertile by serum adiponectin level at the baseline. CV outcome of interest was fatal and non-fatal CV events and all-cause mortality. Progression of CAC was defined as coronary artery calcium score (CACS) change more than 200 during a 4-year follow-up. Results: Cox regression analysis revealed that high serum adiponectin is associated with increased risk of fatal and non-fatal CV events (adjusted hazard ratio 2.799, 95% CI 1.348–5.811). In contrast, high serum adiponectin level was not significantly associated with all-cause mortality (adjusted hazard ratio 0.655, 95% CI 0.203–2.113). Binary logistic regression analysis revealed that high serum adiponectin level is also associated with increased risk of progression of CAC (adjusted odds ratio [OR] 2.078, 95% CI 1.014–4.260). Subgroup analyses demonstrated that the association of high serum adiponectin with increased risk of fatal and non-fatal CV events is not modified by age, gender, history of diabetes, estimated glomerular filtration rate (eGFR), or spot urine albumin-to-creatinine ratio (ACR). Conclusions: High serum adiponectin level is associated with adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.
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spelling pubmed-87928362022-01-28 Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease Suh, Sang Heon Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Lee, Joongyub Oh, Yun Kyu Jung, Ji Yong Lee, Kyu-Beck Oh, Kook-Hwan Ma, Seong Kwon Bae, Eun Hui Kim, Soo Wan Front Cardiovasc Med Cardiovascular Medicine Background: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of high serum adiponectin level with the risk of adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD. Methods: A total of 1,127 patients with pre-dialysis CKD from a nationwide prospective cohort of patients with pre-dialysis CKD in Korea were divided into the tertile by serum adiponectin level at the baseline. CV outcome of interest was fatal and non-fatal CV events and all-cause mortality. Progression of CAC was defined as coronary artery calcium score (CACS) change more than 200 during a 4-year follow-up. Results: Cox regression analysis revealed that high serum adiponectin is associated with increased risk of fatal and non-fatal CV events (adjusted hazard ratio 2.799, 95% CI 1.348–5.811). In contrast, high serum adiponectin level was not significantly associated with all-cause mortality (adjusted hazard ratio 0.655, 95% CI 0.203–2.113). Binary logistic regression analysis revealed that high serum adiponectin level is also associated with increased risk of progression of CAC (adjusted odds ratio [OR] 2.078, 95% CI 1.014–4.260). Subgroup analyses demonstrated that the association of high serum adiponectin with increased risk of fatal and non-fatal CV events is not modified by age, gender, history of diabetes, estimated glomerular filtration rate (eGFR), or spot urine albumin-to-creatinine ratio (ACR). Conclusions: High serum adiponectin level is associated with adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8792836/ /pubmed/35097010 http://dx.doi.org/10.3389/fcvm.2021.789488 Text en Copyright © 2022 Suh, Oh, Choi, Kim, Lee, Oh, Jung, Lee, Oh, Ma, Bae and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Suh, Sang Heon
Oh, Tae Ryom
Choi, Hong Sang
Kim, Chang Seong
Lee, Joongyub
Oh, Yun Kyu
Jung, Ji Yong
Lee, Kyu-Beck
Oh, Kook-Hwan
Ma, Seong Kwon
Bae, Eun Hui
Kim, Soo Wan
Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
title Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
title_full Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
title_fullStr Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
title_full_unstemmed Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
title_short Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease
title_sort association of high serum adiponectin level with adverse cardiovascular outcomes and progression of coronary artery calcification in patients with pre-dialysis chronic kidney disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792836/
https://www.ncbi.nlm.nih.gov/pubmed/35097010
http://dx.doi.org/10.3389/fcvm.2021.789488
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