Alzheimer’s vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling

Whether and how the pathogenic disruptions in endosomal trafficking observed in Alzheimer’s disease (AD) are linked to its anatomical vulnerability remain unknown. Here, we began addressing these questions by showing that neurons are enriched with a second retromer core, organized around VPS26b, dif...

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Detalles Bibliográficos
Autores principales: Simoes, Sabrina, Guo, Jia, Buitrago, Luna, Qureshi, Yasir H., Feng, Xinyang, Kothiya, Milankumar, Cortes, Etty, Patel, Vivek, Kannan, Suvarnambiga, Kim, Young-Hyun, Chang, Kyu-Tae, Hussaini, S. Abid, Moreno, Herman, Di Paolo, Gilbert, Andersen, Olav M., Small, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792909/
https://www.ncbi.nlm.nih.gov/pubmed/34965419
http://dx.doi.org/10.1016/j.celrep.2021.110182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792909/
https://www.ncbi.nlm.nih.gov/pubmed/34965419
http://dx.doi.org/10.1016/j.celrep.2021.110182

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