Positive Feedback Regulation of Poly(ADP-ribose) Polymerase 1 and the DNA-PK Catalytic Subunit Affects the Sensitivity of Nasopharyngeal Carcinoma to Etoposide

[Image: see text] Etoposide (VP-16) is used for the treatment of various cancers, including nasopharyngeal carcinoma (NPC); however, cancers develop resistance to this agent by promoting DNA repair. The DNA-PK (DNA-PKcs) catalytic subunit and poly(ADP-ribose) polymerase 1 (PARP1) mediate acquired re...

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Detalles Bibliográficos
Autores principales: Zhang, Lingyu, Zhuang, Yingting, Tu, Guihui, Li, Ding, Fan, Yingjuan, Ye, Shengnan, Xu, Jianhua, Zheng, Ming, Wu, Ying, Wu, Lixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793086/
https://www.ncbi.nlm.nih.gov/pubmed/35097256
http://dx.doi.org/10.1021/acsomega.1c04379

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