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HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study

High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in developed countries, current diagnostic tests cannot predict if mild lesions may p...

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Autores principales: Zhang, Lina, Shi, Xinyi, Zhang, Qing, Mao, Zhilei, Shi, Xiaoyu, Zhou, Jun, Jian, Aili, Zhu, Renying, Jiang, Shisong, Lu, Wenshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793279/
https://www.ncbi.nlm.nih.gov/pubmed/35095843
http://dx.doi.org/10.3389/fimmu.2021.768144
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author Zhang, Lina
Shi, Xinyi
Zhang, Qing
Mao, Zhilei
Shi, Xiaoyu
Zhou, Jun
Jian, Aili
Zhu, Renying
Jiang, Shisong
Lu, Wenshu
author_facet Zhang, Lina
Shi, Xinyi
Zhang, Qing
Mao, Zhilei
Shi, Xiaoyu
Zhou, Jun
Jian, Aili
Zhu, Renying
Jiang, Shisong
Lu, Wenshu
author_sort Zhang, Lina
collection PubMed
description High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in developed countries, current diagnostic tests cannot predict if mild lesions may progress into invasive lesions or not. In the current cross-sectional and longitudinal clinical study, we found that the HPV16 E7-specific T cell response in peripheral blood mononuclear cells of HPV16-infected patients is related to HPV16 clearance. It contributes to protecting the squamous interaepithelial lesion (SIL) from further malignant development. Of the HPV16 infected women enrolled (n = 131), 42 had neither intraepithelial lesion nor malignancy (NILM), 33 had low-grade SIL, 39 had high-grade SIL, and 17 had cervical cancer. Only one of 17 (5.9%) cancer patients had a positive HPV16 E7-specific T cell response, dramatically lower than the groups of precancer patients. After one year of follow-up, most women (28/33, 84.8%) with persistent HPV infection did not exhibit a HPV16 E7-specific T cell response. Furthermore, 3 malignantly progressed women, one progressed to high-grade SIL and two progressed to low-grade SIL, were negative to the HPV16 E7-specific T cell response. None of the patients with a positive HPV16 E7-specific T cell response progressed to further deterioration. Our observation suggests that HPV16 E7-specific T cell immunity is significant in viral clearance and contributes in protection against progression to malignancy.
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spelling pubmed-87932792022-01-28 HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study Zhang, Lina Shi, Xinyi Zhang, Qing Mao, Zhilei Shi, Xiaoyu Zhou, Jun Jian, Aili Zhu, Renying Jiang, Shisong Lu, Wenshu Front Immunol Immunology High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in developed countries, current diagnostic tests cannot predict if mild lesions may progress into invasive lesions or not. In the current cross-sectional and longitudinal clinical study, we found that the HPV16 E7-specific T cell response in peripheral blood mononuclear cells of HPV16-infected patients is related to HPV16 clearance. It contributes to protecting the squamous interaepithelial lesion (SIL) from further malignant development. Of the HPV16 infected women enrolled (n = 131), 42 had neither intraepithelial lesion nor malignancy (NILM), 33 had low-grade SIL, 39 had high-grade SIL, and 17 had cervical cancer. Only one of 17 (5.9%) cancer patients had a positive HPV16 E7-specific T cell response, dramatically lower than the groups of precancer patients. After one year of follow-up, most women (28/33, 84.8%) with persistent HPV infection did not exhibit a HPV16 E7-specific T cell response. Furthermore, 3 malignantly progressed women, one progressed to high-grade SIL and two progressed to low-grade SIL, were negative to the HPV16 E7-specific T cell response. None of the patients with a positive HPV16 E7-specific T cell response progressed to further deterioration. Our observation suggests that HPV16 E7-specific T cell immunity is significant in viral clearance and contributes in protection against progression to malignancy. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8793279/ /pubmed/35095843 http://dx.doi.org/10.3389/fimmu.2021.768144 Text en Copyright © 2022 Zhang, Shi, Zhang, Mao, Shi, Zhou, Jian, Zhu, Jiang and Lu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Lina
Shi, Xinyi
Zhang, Qing
Mao, Zhilei
Shi, Xiaoyu
Zhou, Jun
Jian, Aili
Zhu, Renying
Jiang, Shisong
Lu, Wenshu
HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study
title HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study
title_full HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study
title_fullStr HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study
title_full_unstemmed HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study
title_short HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study
title_sort hpv-16 e7-specific cellular immune response in women with cervical intraepithelial lesion contributes to viral clearance: a cross-sectional and longitudinal clinical study
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793279/
https://www.ncbi.nlm.nih.gov/pubmed/35095843
http://dx.doi.org/10.3389/fimmu.2021.768144
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