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Diffuse large B-cell lymphoma with uncommon cardiac invasion
Diffuse large B-cell lymphoma is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases, it is uncommon for diffuse large B-cell lymphoma to present as intracardiac mass. A 26-year-old female patient presented with progressive sh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793420/ https://www.ncbi.nlm.nih.gov/pubmed/35096395 http://dx.doi.org/10.1177/2050313X211070942 |
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author | Daralammouri, Yunis Hamayel, Hamza Ismail, Yahya Majadla, Sajed Odeh, Razan |
author_facet | Daralammouri, Yunis Hamayel, Hamza Ismail, Yahya Majadla, Sajed Odeh, Razan |
author_sort | Daralammouri, Yunis |
collection | PubMed |
description | Diffuse large B-cell lymphoma is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases, it is uncommon for diffuse large B-cell lymphoma to present as intracardiac mass. A 26-year-old female patient presented with progressive shortness of breath, facial swelling, and lower limb edema. Imaging investigations by echocardiography and computed tomography showed a large right atrial mass that was obstructing the tricuspid valve. Open biopsy was taken, histopathology showed diffuse large B-cell lymphoma. She received six cycles R-CHOP chemotherapy (rituximab, cyclophosphamide, epirubicin, vincristine, and prednisone) with complete resolution of the mass. Diffuse large B-cell lymphoma can present with atypical and uncommon sites such as the heart as the first presentation. Early diagnosis and appropriate management is crucial given the poor outcome with late presentation. A high index of suspicion and the proper investigations is recommended to allow for early intervention and favorable outcomes as what happened with the case under discussion. |
format | Online Article Text |
id | pubmed-8793420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-87934202022-01-28 Diffuse large B-cell lymphoma with uncommon cardiac invasion Daralammouri, Yunis Hamayel, Hamza Ismail, Yahya Majadla, Sajed Odeh, Razan SAGE Open Med Case Rep Case Report Diffuse large B-cell lymphoma is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases, it is uncommon for diffuse large B-cell lymphoma to present as intracardiac mass. A 26-year-old female patient presented with progressive shortness of breath, facial swelling, and lower limb edema. Imaging investigations by echocardiography and computed tomography showed a large right atrial mass that was obstructing the tricuspid valve. Open biopsy was taken, histopathology showed diffuse large B-cell lymphoma. She received six cycles R-CHOP chemotherapy (rituximab, cyclophosphamide, epirubicin, vincristine, and prednisone) with complete resolution of the mass. Diffuse large B-cell lymphoma can present with atypical and uncommon sites such as the heart as the first presentation. Early diagnosis and appropriate management is crucial given the poor outcome with late presentation. A high index of suspicion and the proper investigations is recommended to allow for early intervention and favorable outcomes as what happened with the case under discussion. SAGE Publications 2022-01-25 /pmc/articles/PMC8793420/ /pubmed/35096395 http://dx.doi.org/10.1177/2050313X211070942 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Daralammouri, Yunis Hamayel, Hamza Ismail, Yahya Majadla, Sajed Odeh, Razan Diffuse large B-cell lymphoma with uncommon cardiac invasion |
title | Diffuse large B-cell lymphoma with uncommon cardiac invasion |
title_full | Diffuse large B-cell lymphoma with uncommon cardiac invasion |
title_fullStr | Diffuse large B-cell lymphoma with uncommon cardiac invasion |
title_full_unstemmed | Diffuse large B-cell lymphoma with uncommon cardiac invasion |
title_short | Diffuse large B-cell lymphoma with uncommon cardiac invasion |
title_sort | diffuse large b-cell lymphoma with uncommon cardiac invasion |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793420/ https://www.ncbi.nlm.nih.gov/pubmed/35096395 http://dx.doi.org/10.1177/2050313X211070942 |
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