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IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy
Normal pregnancy is related to the successful transition from type 1 cellular immunity to type 2 cellular immunity. Therefore, this study aimed to investigate whether there is abnormal expression of cytokines in the process of inducing Recurrent spontaneous abortion (RSA). Interleukin (IL)-33 is a n...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793670/ https://www.ncbi.nlm.nih.gov/pubmed/35095557 http://dx.doi.org/10.3389/fphys.2021.789829 |
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author | Zhao, Long Fu, Jinhua Ding, Feng Liu, Juan Li, Lin Song, Qi Fu, Yinghui |
author_facet | Zhao, Long Fu, Jinhua Ding, Feng Liu, Juan Li, Lin Song, Qi Fu, Yinghui |
author_sort | Zhao, Long |
collection | PubMed |
description | Normal pregnancy is related to the successful transition from type 1 cellular immunity to type 2 cellular immunity. Therefore, this study aimed to investigate whether there is abnormal expression of cytokines in the process of inducing Recurrent spontaneous abortion (RSA). Interleukin (IL)-33 is a new member of the IL-1 family, and ST2, as IL-33’s receptor, induced the production of type 2 cytokines. In this study, blood samples were collected from 19 non-pregnant women of normal childbearing age, 28 normal pregnant women, and 33 women with RSA. The serum concentrations of IL-33 and ST2 were detected by flow cytometry. Our results showed that the serum concentrations of IL-33 and ST2 in the RSA group were significantly higher than those in the healthy control group (IL-33: P < 0.05; ST2: P < 0.0001), and IL-33 and ST2 had a higher level in the process of RSA predictive value. In addition, this study initially found that the serum concentrations of IL-33 and ST2 were not significantly correlated with the number of weeks of pregnancy, and there was a lower correlation between IL-33 and ST2 during RSA. This result may be related to the small number of cases. This study is the first time to correlate the changes in serum concentrations of IL-33 and ST2 with RSA, which may be a novel biomarker for the prediction and treatment of RSA. |
format | Online Article Text |
id | pubmed-8793670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87936702022-01-28 IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy Zhao, Long Fu, Jinhua Ding, Feng Liu, Juan Li, Lin Song, Qi Fu, Yinghui Front Physiol Physiology Normal pregnancy is related to the successful transition from type 1 cellular immunity to type 2 cellular immunity. Therefore, this study aimed to investigate whether there is abnormal expression of cytokines in the process of inducing Recurrent spontaneous abortion (RSA). Interleukin (IL)-33 is a new member of the IL-1 family, and ST2, as IL-33’s receptor, induced the production of type 2 cytokines. In this study, blood samples were collected from 19 non-pregnant women of normal childbearing age, 28 normal pregnant women, and 33 women with RSA. The serum concentrations of IL-33 and ST2 were detected by flow cytometry. Our results showed that the serum concentrations of IL-33 and ST2 in the RSA group were significantly higher than those in the healthy control group (IL-33: P < 0.05; ST2: P < 0.0001), and IL-33 and ST2 had a higher level in the process of RSA predictive value. In addition, this study initially found that the serum concentrations of IL-33 and ST2 were not significantly correlated with the number of weeks of pregnancy, and there was a lower correlation between IL-33 and ST2 during RSA. This result may be related to the small number of cases. This study is the first time to correlate the changes in serum concentrations of IL-33 and ST2 with RSA, which may be a novel biomarker for the prediction and treatment of RSA. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8793670/ /pubmed/35095557 http://dx.doi.org/10.3389/fphys.2021.789829 Text en Copyright © 2022 Zhao, Fu, Ding, Liu, Li, Song and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Zhao, Long Fu, Jinhua Ding, Feng Liu, Juan Li, Lin Song, Qi Fu, Yinghui IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy |
title | IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy |
title_full | IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy |
title_fullStr | IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy |
title_full_unstemmed | IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy |
title_short | IL-33 and Soluble ST2 Are Associated With Recurrent Spontaneous Abortion in Early Pregnancy |
title_sort | il-33 and soluble st2 are associated with recurrent spontaneous abortion in early pregnancy |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793670/ https://www.ncbi.nlm.nih.gov/pubmed/35095557 http://dx.doi.org/10.3389/fphys.2021.789829 |
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