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Post-hoc Analysis of Pharmacodynamics and Single-Agent Activity of CD3xCD123 Bispecific Antibody APVO436 in Relapsed/Refractory AML and MDS Resistant to HMA or Venetoclax Plus HMA

APVO436 is a recombinant bispecific antibody designed to direct host cytotoxic T-cells to CD123-expressing blast cells in patients with hematologic malignancies. APVO436 showed promising tolerability and single-agent activity in relapsed or refractory (R/R) acute myeloid leukemia (AML) and myelodysp...

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Detalles Bibliográficos
Autores principales:	Watts, Justin, Lin, Tara L., Mims, Alice, Patel, Prapti, Lee, Cynthia, Shahidzadeh, Anoush, Shami, Paul, Cull, Elizabeth, Cogle, Christopher R., Wang, Eunice, Uckun, Fatih M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793782/ https://www.ncbi.nlm.nih.gov/pubmed/35096610 http://dx.doi.org/10.3389/fonc.2021.806243

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