Cargando…

The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates

Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The resulting glucuronide and sulfate conjugates are generally considered inactive and safe. They may, however, be the most prominent drug-related material in the circulation and excreta of humans. The glucuron...

Descripción completa

Detalles Bibliográficos
Autores principales:	Järvinen, Erkka, Deng, Feng, Kiander, Wilma, Sinokki, Alli, Kidron, Heidi, Sjöstedt, Noora
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793843/ https://www.ncbi.nlm.nih.gov/pubmed/35095509 http://dx.doi.org/10.3389/fphar.2021.802539

Ejemplares similares

The Effect of Albumin on MRP2 and BCRP in the Vesicular Transport Assay
por: Deng, Feng, et al.
Publicado: (2016)

Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2
por: Sjöstedt, Noora, et al.
Publicado: (2017)

Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate
por: Kong, Ling-Lei, et al.
Publicado: (2016)

Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis
por: Zeng, Wanying, et al.
Publicado: (2022)

Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling
por: Gramec Skledar, Darja, et al.
Publicado: (2018)

The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors
por: Qin, Zifei, et al.
Publicado: (2019)

Species differences in sinusoidal and canalicular efflux transport of mycophenolic acid 7-O-glucuronide in sandwich-cultured hepatocytes
por: Tetsuka, Kazuhiro, et al.
Publicado: (2014)

Enantiospecific Pharmacogenomics of Fluvastatin
por: Hirvensalo, Päivi, et al.
Publicado: (2019)

Influence of OATP1B1 Function on the Disposition of Sorafenib‐β‐D‐Glucuronide
por: Bins, S, et al.
Publicado: (2017)

Interaction of Chrysin and Its Main Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide with Serum Albumin
por: Mohos, Violetta, et al.
Publicado: (2018)

Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
por: Gueorguieva, Ralitza, et al.
Publicado: (2022)

Regulation of ABC Drug Efflux Transporters in Human T-Cells Exposed to an HIV Pseudotype
por: Whyte-Allman, Sana-Kay, et al.
Publicado: (2021)

Commentary on: “Influence of OATP1B1 Function on the Disposition of Sorafenib‐β‐D‐Glucuronide”
por: Morrissey, KM, et al.
Publicado: (2017)

Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats
por: INOUE, Hiroki, et al.
Publicado: (2016)

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality
por: Kiander, Wilma, et al.
Publicado: (2021)

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice
por: Fendt, Rebekka, et al.
Publicado: (2023)

P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses
por: Ho, Harvey, et al.
Publicado: (2023)

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1
por: Zhang, Beibei, et al.
Publicado: (2019)

Identification of naturally occurring inhibitors in Xian-Ling-Gu-Bao capsule against the glucuronidation of estrogens
por: He, Liangliang, et al.
Publicado: (2022)

Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients
por: Wang, Ling-Zhi, et al.
Publicado: (2013)

Interactions Between Emodin and Efflux Transporters on Rat Enterocyte by a Validated Ussing Chamber Technique
por: Huang, Juan, et al.
Publicado: (2018)

Contribution of Uptake and Efflux Transporters to Oral Pharmacokinetics of Furosemide
por: Chapa, Revathi, et al.
Publicado: (2020)

P-glycoprotein mediated efflux limits substrate and drug uptake in a preclinical brain metastases of breast cancer model
por: Adkins, Chris E., et al.
Publicado: (2013)

Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.
por: Burchell, B, et al.
Publicado: (1997)

Value of Ethyl Glucuronide and Ethyl Sulfate in Serum as Biomarkers of Alcohol Consumption
por: Shukla, Lekhansh, et al.
Publicado: (2017)

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro
por: Liu, Xia-Wen, et al.
Publicado: (2018)

Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition
por: Parvez, Md Masud, et al.
Publicado: (2023)

Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems()
por: Wlcek, Katrin, et al.
Publicado: (2014)

Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction?
por: Wenzel, Christoph, et al.
Publicado: (2021)

The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro
por: Khabbazi, Samira, et al.
Publicado: (2016)

Correction: Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients
por: Wang, Ling-Zhi, et al.
Publicado: (2014)

Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2
por: Xu, Peng, et al.
Publicado: (2018)

Identification of Critical Residues in the Carboxy Terminus of the Dopamine Transporter Involved in the G Protein βγ-Induced Dopamine Efflux
por: Pino, José A., et al.
Publicado: (2021)

Synthesis, Characterization, Cellular Uptake, and In Vitro Anticancer Activity of Fullerenol-Doxorubicin Conjugates
por: Xu, Beihua, et al.
Publicado: (2021)

In Vitro Glucuronidation and Sulfation of ε-Viniferin, a Resveratrol Dimer, in Humans and Rats
por: Courtois, Arnaud, et al.
Publicado: (2017)

Intracellular disposition of chitosan nanoparticles in macrophages: intracellular uptake, exocytosis, and intercellular transport
por: Jiang, Li Qun, et al.
Publicado: (2017)

Exposure Characteristics of the Analogous β-Carboline Alkaloids Harmaline and Harmine Based on the Efflux Transporter of Multidrug Resistance Protein 2
por: Li, Shuping, et al.
Publicado: (2017)

Quantitative Determination of Common Urinary Odorants and Their Glucuronide Conjugates in Human Urine
por: Wagenstaller, Maria, et al.
Publicado: (2013)

Determination of Serotonin and Dopamine Metabolites in Human Brain Microdialysis and Cerebrospinal Fluid Samples by UPLC-MS/MS: Discovery of Intact Glucuronide and Sulfate Conjugates
por: Suominen, Tina, et al.
Publicado: (2013)

Efflux pump proteins in antifungal resistance
por: Prasad, Rajendra, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7djuo1rjehvp1cril2l8ubn74n