Cargando…

Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Older individuals are at higher risk of SARS-CoV-2 infection and severe outcomes, but the underlying mechanisms are incompletely understood. In addition, how age modulates SARS-CoV-2 re-infection and vaccine breakthrough infections remain largely unexplored. Here, we investigated age-associated SARS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yanxia, Li, Can, Liu, Feifei, Ye, Zhanhong, Song, Wenchen, Lee, Andrew C. Y., Shuai, Huiping, Lu, Lu, To, Kelvin Kai-Wang, Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Chu, Hin, Yuen, Kwok-Yung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Coronaviruses
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794076/ https://www.ncbi.nlm.nih.gov/pubmed/34989330 http://dx.doi.org/10.1080/22221751.2022.2026741

Ejemplares similares

Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters
por: Li, Can, et al.
Publicado: (2023)

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
por: Zhang, Xi, et al.
Publicado: (2022)

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2
por: Hu, Bingjie, et al.
Publicado: (2022)

Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants
por: Zhao, Hanjun, et al.
Publicado: (2022)

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection
por: Ye, Zi-Wei, et al.
Publicado: (2021)

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage
por: Liang, Ronghui, et al.
Publicado: (2022)

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells
por: Zhao, Hanjun, et al.
Publicado: (2022)

Preparation for the next pandemic: challenges in strengthening surveillance
por: Chiu, Kelvin Hei-Yeung, et al.
Publicado: (2023)

SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters(1)
por: Zhou, Biao, et al.
Publicado: (2023)

SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong
por: Poon, Rosana Wing-Shan, et al.
Publicado: (2022)

Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model
por: Li, Can, et al.
Publicado: (2021)

Correlations of Myeloperoxidase (MPO), Adenosine deaminase (ADA), C–C motif chemokine 22 (CCL22), Tumour necrosis factor alpha (TNFα) and Interleukin-6 (IL-6) mRNA expression in the nasopharyngeal specimens with the diagnosis and severity of SARS-CoV-2 infections
por: Chiu, Kelvin Hei-Yeung, et al.
Publicado: (2023)

Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine
por: Chen, Lin-Lei, et al.
Publicado: (2022)

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis
por: Zhou, Jie, et al.
Publicado: (2015)

A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants
por: Lam, Joy-Yan, et al.
Publicado: (2022)

Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination(1)
por: Wang, Hongyu, et al.
Publicado: (2023)

Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters
por: Zhang, Anna Jinxia, et al.
Publicado: (2020)

Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2
por: Luo, Mengxiao, et al.
Publicado: (2023)

Assessment of vaccinations and breakthrough infections after adjustment of the dynamic zero-COVID-19 strategy in China: an online survey
por: Qin, Shijie, et al.
Publicado: (2023)

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses
por: Wang, Pengfei, et al.
Publicado: (2021)

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2020)

COVID-19 breakthrough infections and humoral immune response among BNT162b2 vaccinated healthcare workers in Malaysia
por: Yang, Su Lan, et al.
Publicado: (2022)

COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses
por: Chen, Yanxia, et al.
Publicado: (2023)

A lethal mouse model using a mouse-adapted SARS-CoV-2 strain with enhanced binding to mouse ACE2 as an important platform for COVID-19 research
por: Chu, Hin, et al.
Publicado: (2021)

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation
por: Zhang, Xi, et al.
Publicado: (2020)

Dynamics of viral shedding during ancestral or Omicron BA.1 SARS-CoV-2 infection and enhancement of pre-existing immunity during breakthrough infections
por: Saade, Carla, et al.
Publicado: (2022)

Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters
por: Lee, Andrew Chak-Yiu, et al.
Publicado: (2020)

Lessons learned from the fifth wave of COVID-19 in Hong Kong in early 2022
por: Cheung, Pak-Hin Hinson, et al.
Publicado: (2022)

Cross-species transmission and emergence of novel viruses from birds
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2015)

Host genes and influenza pathogenesis in humans: an emerging paradigm
por: To, Kelvin Kai-Wang, et al.
Publicado: (2015)

Sera from breakthrough infections with SARS-CoV-2 BA.5 or BF.7 showed lower neutralization activity against XBB.1.5 and CH.1.1
por: Liu, Shuo, et al.
Publicado: (2023)

Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong
por: Kok, Kin-Hang, et al.
Publicado: (2022)

Mouse study of combined DNA/protein COVID-19 vaccine to boost high levels of antibody and cell mediated immune responses
por: He, Qian, et al.
Publicado: (2022)

An engineered recombinant protein containing three structural domains in SARS-CoV-2 S2 protein has potential to act as a pan-human coronavirus entry inhibitor or vaccine antigen
por: Wang, Xinling, et al.
Publicado: (2023)

Interspecies transmission and emergence of novel viruses: lessons from bats and birds
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2013)

SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors
por: Xia, Shuai, et al.
Publicado: (2023)

Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer
por: Shuai, Huiping, et al.
Publicado: (2020)

Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019
por: Chua, Gilbert T., et al.
Publicado: (2021)

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication
por: Yan, Bingpeng, et al.
Publicado: (2019)

Medium-term outcomes of myocarditis and pericarditis following BNT162b2 vaccination among adolescents in Hong Kong
por: Chua, Gilbert T., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gfcrehl9jnfdvhmj4dug1hd5pp