Cargando…

Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course

The Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Lombardi, Raúl, Ferreiro, Alejandro, Ponce, Daniela, Claure-Del Granado, Rolando, Aroca, Gustavo, Venegas, Yanissa, Pereira, Mariana, Chavez-Iñiguez, Jonathan, Rojas, Nelson, Villa, Ana, Colombo, Marcos, Carlino, Cristina, Guimarâes, Caio, Younes-Ibrahim, Mauricio, Rizo, Lilia Maria, Guzmán, Gisselle, Varela, Carlos, Rosa-Diez, Guillermo, Janiques, Diego, Ayala, Roger, Coronel, Galo, Roessler, Eric, Amor, Serena, Osorio, Washington, Rivas, Natalia, Pereira, Benedito, de Azevedo, Caroline, Flores, Adriana, Ubillo, José, Raño, Julieta, Yu, Luis, Burdmann, Emmanuel A., Rodríguez, Luis, Galagarza-Gutiérrez, Gianny, Curitomay-Cruz, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794101/
https://www.ncbi.nlm.nih.gov/pubmed/35085273
http://dx.doi.org/10.1371/journal.pone.0261764
_version_ 1784640752581607424
author Lombardi, Raúl
Ferreiro, Alejandro
Ponce, Daniela
Claure-Del Granado, Rolando
Aroca, Gustavo
Venegas, Yanissa
Pereira, Mariana
Chavez-Iñiguez, Jonathan
Rojas, Nelson
Villa, Ana
Colombo, Marcos
Carlino, Cristina
Guimarâes, Caio
Younes-Ibrahim, Mauricio
Rizo, Lilia Maria
Guzmán, Gisselle
Varela, Carlos
Rosa-Diez, Guillermo
Janiques, Diego
Ayala, Roger
Coronel, Galo
Roessler, Eric
Amor, Serena
Osorio, Washington
Rivas, Natalia
Pereira, Benedito
de Azevedo, Caroline
Flores, Adriana
Ubillo, José
Raño, Julieta
Yu, Luis
Burdmann, Emmanuel A.
Rodríguez, Luis
Galagarza-Gutiérrez, Gianny
Curitomay-Cruz, Jesús
author_facet Lombardi, Raúl
Ferreiro, Alejandro
Ponce, Daniela
Claure-Del Granado, Rolando
Aroca, Gustavo
Venegas, Yanissa
Pereira, Mariana
Chavez-Iñiguez, Jonathan
Rojas, Nelson
Villa, Ana
Colombo, Marcos
Carlino, Cristina
Guimarâes, Caio
Younes-Ibrahim, Mauricio
Rizo, Lilia Maria
Guzmán, Gisselle
Varela, Carlos
Rosa-Diez, Guillermo
Janiques, Diego
Ayala, Roger
Coronel, Galo
Roessler, Eric
Amor, Serena
Osorio, Washington
Rivas, Natalia
Pereira, Benedito
de Azevedo, Caroline
Flores, Adriana
Ubillo, José
Raño, Julieta
Yu, Luis
Burdmann, Emmanuel A.
Rodríguez, Luis
Galagarza-Gutiérrez, Gianny
Curitomay-Cruz, Jesús
author_sort Lombardi, Raúl
collection PubMed
description The Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54–74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.
format Online
Article
Text
id pubmed-8794101
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-87941012022-01-28 Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course Lombardi, Raúl Ferreiro, Alejandro Ponce, Daniela Claure-Del Granado, Rolando Aroca, Gustavo Venegas, Yanissa Pereira, Mariana Chavez-Iñiguez, Jonathan Rojas, Nelson Villa, Ana Colombo, Marcos Carlino, Cristina Guimarâes, Caio Younes-Ibrahim, Mauricio Rizo, Lilia Maria Guzmán, Gisselle Varela, Carlos Rosa-Diez, Guillermo Janiques, Diego Ayala, Roger Coronel, Galo Roessler, Eric Amor, Serena Osorio, Washington Rivas, Natalia Pereira, Benedito de Azevedo, Caroline Flores, Adriana Ubillo, José Raño, Julieta Yu, Luis Burdmann, Emmanuel A. Rodríguez, Luis Galagarza-Gutiérrez, Gianny Curitomay-Cruz, Jesús PLoS One Research Article The Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54–74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course. Public Library of Science 2022-01-27 /pmc/articles/PMC8794101/ /pubmed/35085273 http://dx.doi.org/10.1371/journal.pone.0261764 Text en © 2022 Lombardi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lombardi, Raúl
Ferreiro, Alejandro
Ponce, Daniela
Claure-Del Granado, Rolando
Aroca, Gustavo
Venegas, Yanissa
Pereira, Mariana
Chavez-Iñiguez, Jonathan
Rojas, Nelson
Villa, Ana
Colombo, Marcos
Carlino, Cristina
Guimarâes, Caio
Younes-Ibrahim, Mauricio
Rizo, Lilia Maria
Guzmán, Gisselle
Varela, Carlos
Rosa-Diez, Guillermo
Janiques, Diego
Ayala, Roger
Coronel, Galo
Roessler, Eric
Amor, Serena
Osorio, Washington
Rivas, Natalia
Pereira, Benedito
de Azevedo, Caroline
Flores, Adriana
Ubillo, José
Raño, Julieta
Yu, Luis
Burdmann, Emmanuel A.
Rodríguez, Luis
Galagarza-Gutiérrez, Gianny
Curitomay-Cruz, Jesús
Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
title Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
title_full Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
title_fullStr Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
title_full_unstemmed Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
title_short Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course
title_sort latin american registry of renal involvement in covid-19 disease. the relevance of assessing proteinuria throughout the clinical course
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794101/
https://www.ncbi.nlm.nih.gov/pubmed/35085273
http://dx.doi.org/10.1371/journal.pone.0261764
work_keys_str_mv AT lombardiraul latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT ferreiroalejandro latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT poncedaniela latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT clauredelgranadorolando latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT arocagustavo latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT venegasyanissa latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT pereiramariana latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT chaveziniguezjonathan latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT rojasnelson latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT villaana latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT colombomarcos latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT carlinocristina latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT guimaraescaio latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT younesibrahimmauricio latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT rizoliliamaria latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT guzmangisselle latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT varelacarlos latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT rosadiezguillermo latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT janiquesdiego latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT ayalaroger latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT coronelgalo latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT roesslereric latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT amorserena latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT osoriowashington latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT rivasnatalia latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT pereirabenedito latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT deazevedocaroline latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT floresadriana latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT ubillojose latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT ranojulieta latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT yuluis latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT burdmannemmanuela latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT rodriguezluis latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT galagarzagutierrezgianny latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse
AT curitomaycruzjesus latinamericanregistryofrenalinvolvementincovid19diseasetherelevanceofassessingproteinuriathroughouttheclinicalcourse