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Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis

OBJECTIVE: The main purpose of this study was to investigate the pooled prevalence of prediabetes and type-2 diabetes in the general population of Malaysia. METHOD: We systematically searched Medline (PubMed), Embase, Web of Science, Google Scholar and Malaysian Journals Online to identify relevant...

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Autores principales: Akhtar, Sohail, Nasir, Jamal Abdul, Ali, Aqsa, Asghar, Mubeen, Majeed, Rizwana, Sarwar, Aqsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794132/
https://www.ncbi.nlm.nih.gov/pubmed/35085366
http://dx.doi.org/10.1371/journal.pone.0263139
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author Akhtar, Sohail
Nasir, Jamal Abdul
Ali, Aqsa
Asghar, Mubeen
Majeed, Rizwana
Sarwar, Aqsa
author_facet Akhtar, Sohail
Nasir, Jamal Abdul
Ali, Aqsa
Asghar, Mubeen
Majeed, Rizwana
Sarwar, Aqsa
author_sort Akhtar, Sohail
collection PubMed
description OBJECTIVE: The main purpose of this study was to investigate the pooled prevalence of prediabetes and type-2 diabetes in the general population of Malaysia. METHOD: We systematically searched Medline (PubMed), Embase, Web of Science, Google Scholar and Malaysian Journals Online to identify relevant studies published between January 1, 1995, and November 30, 2021, on the prevalence of type-2 diabetes in Malaysia. Random-effects meta-analyses were used to obtain the pooled prevalence of diabetes and prediabetes. Subgroup analyses also used to analyze to the potential sources of heterogeneity. Meta- regression was carried to assess associations between study characteristics and diabetes prevalence. Three independent authors selected studies and conducted the quality assessment. The quality of the final evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. RESULTS: Of 2689 potentially relevant studies, 786 titles and abstract were screened. Fifteen studies with 103063 individuals were eligible to be included in the meta-analyses. The pooled prevalence of diabetes was 14.39% (95% CI, 12.51%–16.38%; I(2) = 98.4%, 103063 participants from 15 studies). The pooled prevalence of prediabetes was 11.62% (95% CI, 7.17%–16.97%; I(2) = 99.8, 88702 participants from 9 studies). The subgroup analysis showed statistically significant differences in diabetes prevalence by the ethical sub-populations with highest in Indians (25.10%; 95% CI, 20.19%–30.35%), followed by Malays (15.25%; 95% CI, 11.59%–19.29%), Chinese (12.87%; 95% CI, 9.73%–16.37%), Bumiputeras (8.62%; 95% CI, 5.41%–12.47%) and others (6.91%; 95% CI, 5.71%–8.19%). There was no evidence of publication bias, although heterogeneity was high (I(2) ranged from 0.00% to 99·8%). The quality of evidence based on GRADE was low. CONCLUSIONS: Results of this study suggest that a high prevalence of prediabetes and diabetes in Malaysia. The diabetes prevalence is associated with time period and increasing age. The Malaysian government should develop a comprehensive approach and strategy to enhance diabetes awareness, control, prevention, and treatment. TRIAL REGISTRATION: Trial registration no. PROSPERO CRD42021255894; https://clinicaltrials.gov/.
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spelling pubmed-87941322022-01-28 Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis Akhtar, Sohail Nasir, Jamal Abdul Ali, Aqsa Asghar, Mubeen Majeed, Rizwana Sarwar, Aqsa PLoS One Research Article OBJECTIVE: The main purpose of this study was to investigate the pooled prevalence of prediabetes and type-2 diabetes in the general population of Malaysia. METHOD: We systematically searched Medline (PubMed), Embase, Web of Science, Google Scholar and Malaysian Journals Online to identify relevant studies published between January 1, 1995, and November 30, 2021, on the prevalence of type-2 diabetes in Malaysia. Random-effects meta-analyses were used to obtain the pooled prevalence of diabetes and prediabetes. Subgroup analyses also used to analyze to the potential sources of heterogeneity. Meta- regression was carried to assess associations between study characteristics and diabetes prevalence. Three independent authors selected studies and conducted the quality assessment. The quality of the final evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. RESULTS: Of 2689 potentially relevant studies, 786 titles and abstract were screened. Fifteen studies with 103063 individuals were eligible to be included in the meta-analyses. The pooled prevalence of diabetes was 14.39% (95% CI, 12.51%–16.38%; I(2) = 98.4%, 103063 participants from 15 studies). The pooled prevalence of prediabetes was 11.62% (95% CI, 7.17%–16.97%; I(2) = 99.8, 88702 participants from 9 studies). The subgroup analysis showed statistically significant differences in diabetes prevalence by the ethical sub-populations with highest in Indians (25.10%; 95% CI, 20.19%–30.35%), followed by Malays (15.25%; 95% CI, 11.59%–19.29%), Chinese (12.87%; 95% CI, 9.73%–16.37%), Bumiputeras (8.62%; 95% CI, 5.41%–12.47%) and others (6.91%; 95% CI, 5.71%–8.19%). There was no evidence of publication bias, although heterogeneity was high (I(2) ranged from 0.00% to 99·8%). The quality of evidence based on GRADE was low. CONCLUSIONS: Results of this study suggest that a high prevalence of prediabetes and diabetes in Malaysia. The diabetes prevalence is associated with time period and increasing age. The Malaysian government should develop a comprehensive approach and strategy to enhance diabetes awareness, control, prevention, and treatment. TRIAL REGISTRATION: Trial registration no. PROSPERO CRD42021255894; https://clinicaltrials.gov/. Public Library of Science 2022-01-27 /pmc/articles/PMC8794132/ /pubmed/35085366 http://dx.doi.org/10.1371/journal.pone.0263139 Text en © 2022 Akhtar et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Akhtar, Sohail
Nasir, Jamal Abdul
Ali, Aqsa
Asghar, Mubeen
Majeed, Rizwana
Sarwar, Aqsa
Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis
title Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis
title_full Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis
title_fullStr Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis
title_full_unstemmed Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis
title_short Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis
title_sort prevalence of type-2 diabetes and prediabetes in malaysia: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794132/
https://www.ncbi.nlm.nih.gov/pubmed/35085366
http://dx.doi.org/10.1371/journal.pone.0263139
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