Effects of soluble guanylate cyclase stimulator on renal function in ZSF-1 model of diabetic nephropathy

BACKGROUND: Diabetic nephropathy is associated with endothelial dysfunction and oxidative stress, in which the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling pathway is impaired. We hypothesize that sGC stimulator Compound 1 can enhance NO signaling, re...

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Detalles Bibliográficos
Autores principales: Hu, Lufei, Chen, Yinhong, Zhou, Xiaoyan, Hoek, Maarten, Cox, Jason, Lin, Ken, Liu, Yang, Blumenschein, Wendy, Grein, Jeff, Swaminath, Gayathri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794189/
https://www.ncbi.nlm.nih.gov/pubmed/35085251
http://dx.doi.org/10.1371/journal.pone.0261000

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