Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody

Anti-drug antibodies (ADA) can limit the efficacy and safety of therapeutic antibodies. However, determining the exact nature of ADA interactions with the target drug via epitope mapping is challenging due to the polyclonal nature of the IgG response. Here, we demonstrate successful proof-of-concept...

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Detalles Bibliográficos
Autores principales: Schick, Arthur J., Lundin, Victor, Low, Justin, Peng, Kun, Vandlen, Richard, Wecksler, Aaron T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794239/
https://www.ncbi.nlm.nih.gov/pubmed/35072596
http://dx.doi.org/10.1080/19420862.2022.2028337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794239/
https://www.ncbi.nlm.nih.gov/pubmed/35072596
http://dx.doi.org/10.1080/19420862.2022.2028337

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