Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

Igf2bp1 is an oncofetal RNA binding protein whose expression in numerous types of cancers is associated with upregulation of key pro-oncogenic RNAs, poor prognosis, and reduced survival. Importantly, Igf2bp1 synergizes with mutations in Kras to enhance signalling and oncogenic activity, suggesting t...

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Detalles Bibliográficos
Autores principales: Wallis, Nadav, Oberman, Froma, Shurrush, Khriesto, Germain, Nicolas, Greenwald, Gila, Gershon, Tehila, Pearl, Talia, Abis, Giancarlo, Singh, Vikash, Singh, Amandeep, Sharma, Arun K., Barr, Haim M., Ramos, Andres, Spiegelman, Vladimir S., Yisraeli, Joel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794255/
https://www.ncbi.nlm.nih.gov/pubmed/34895045
http://dx.doi.org/10.1080/15476286.2021.2010983

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