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An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur

Biomechanical testing is a necessity given the development of novel implants used in the osteosynthesis of hip fractures. The purpose of biomechanical testing is to recreate realistic conditions similar to the in vivo conditions. Although biomechanical testing of hip arthroplasty has been standardiz...

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Autores principales: Gheorghevici, Teodor Stefan, Carata, Eugen, Sirbu, Paul-Dan, Alexa, Ovidiu, Poroh, Manuela-Gabi, Filip, Alexandru, Forna, Norin, Puha, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794553/
https://www.ncbi.nlm.nih.gov/pubmed/35126705
http://dx.doi.org/10.3892/etm.2022.11125
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author Gheorghevici, Teodor Stefan
Carata, Eugen
Sirbu, Paul-Dan
Alexa, Ovidiu
Poroh, Manuela-Gabi
Filip, Alexandru
Forna, Norin
Puha, Bogdan
author_facet Gheorghevici, Teodor Stefan
Carata, Eugen
Sirbu, Paul-Dan
Alexa, Ovidiu
Poroh, Manuela-Gabi
Filip, Alexandru
Forna, Norin
Puha, Bogdan
author_sort Gheorghevici, Teodor Stefan
collection PubMed
description Biomechanical testing is a necessity given the development of novel implants used in the osteosynthesis of hip fractures. The purpose of biomechanical testing is to recreate realistic conditions similar to the in vivo conditions. Although biomechanical testing of hip arthroplasty has been standardized since the 1970s, there is no consensus at present on testing methodology for osteosynthesis of hip fractures. Most biomechanical studies examining the fractures of the proximal femur in order to optimize implants opt for loading the bone-implant ensemble directly on the femoral head or using a metallic loading part. This loading technique fails to perform a mechanical stress distribution similar to in vivo conditions, which could alter the outcome. The present study aimed to design loading/unloading cups with mechanical properties that resemble those of the cartilage at the hip level. Through the impression and scanning of the cast models obtained, a digital 3D model was created in STL format and this was processed in order to obtain the computer numerical control (CNC) trajectories of the printing head. For prototyping using additive manufacturing technology, a thermoplastic polymer with biochemical properties, such as tensile strength, that resemble those of the adult hip and a Stratasys FORTUS 250 mc CNC machine were used. Loading/unloading cups with similar anatomy and biomechanical forces compared with those of the adult hip were created, which allowed the experimental simulation of the conditions during walking.
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spelling pubmed-87945532022-02-03 An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur Gheorghevici, Teodor Stefan Carata, Eugen Sirbu, Paul-Dan Alexa, Ovidiu Poroh, Manuela-Gabi Filip, Alexandru Forna, Norin Puha, Bogdan Exp Ther Med Articles Biomechanical testing is a necessity given the development of novel implants used in the osteosynthesis of hip fractures. The purpose of biomechanical testing is to recreate realistic conditions similar to the in vivo conditions. Although biomechanical testing of hip arthroplasty has been standardized since the 1970s, there is no consensus at present on testing methodology for osteosynthesis of hip fractures. Most biomechanical studies examining the fractures of the proximal femur in order to optimize implants opt for loading the bone-implant ensemble directly on the femoral head or using a metallic loading part. This loading technique fails to perform a mechanical stress distribution similar to in vivo conditions, which could alter the outcome. The present study aimed to design loading/unloading cups with mechanical properties that resemble those of the cartilage at the hip level. Through the impression and scanning of the cast models obtained, a digital 3D model was created in STL format and this was processed in order to obtain the computer numerical control (CNC) trajectories of the printing head. For prototyping using additive manufacturing technology, a thermoplastic polymer with biochemical properties, such as tensile strength, that resemble those of the adult hip and a Stratasys FORTUS 250 mc CNC machine were used. Loading/unloading cups with similar anatomy and biomechanical forces compared with those of the adult hip were created, which allowed the experimental simulation of the conditions during walking. D.A. Spandidos 2022-03 2022-01-05 /pmc/articles/PMC8794553/ /pubmed/35126705 http://dx.doi.org/10.3892/etm.2022.11125 Text en Copyright: © Gheorghevici et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Gheorghevici, Teodor Stefan
Carata, Eugen
Sirbu, Paul-Dan
Alexa, Ovidiu
Poroh, Manuela-Gabi
Filip, Alexandru
Forna, Norin
Puha, Bogdan
An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
title An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
title_full An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
title_fullStr An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
title_full_unstemmed An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
title_short An original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
title_sort original method of simulating the articular cartilage in the context of in vitro biomechanical studies investigating the proximal femur
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794553/
https://www.ncbi.nlm.nih.gov/pubmed/35126705
http://dx.doi.org/10.3892/etm.2022.11125
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