Cargando…

Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study

BACKGROUND & OBJECTIVE: Colorectal cancer is the third most common cause of cancer death worldwide. Stanniocalcin 2 (STC2) is a glycoprotein hormone over-expressed in many human cancers where it regulates tumor progression and invasion. Evaluating its expression in colorectal cancer and its rela...

Descripción completa

Detalles Bibliográficos
Autores principales: El hanbuli, Hala M., Galal, Rehab S., Darweesh, Mohammed F., Elmahdi, Mohamed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794563/
https://www.ncbi.nlm.nih.gov/pubmed/35096084
http://dx.doi.org/10.30699/IJP.2021-.521799.2559
_version_ 1784640840840249344
author El hanbuli, Hala M.
Galal, Rehab S.
Darweesh, Mohammed F.
Elmahdi, Mohamed H.
author_facet El hanbuli, Hala M.
Galal, Rehab S.
Darweesh, Mohammed F.
Elmahdi, Mohamed H.
author_sort El hanbuli, Hala M.
collection PubMed
description BACKGROUND & OBJECTIVE: Colorectal cancer is the third most common cause of cancer death worldwide. Stanniocalcin 2 (STC2) is a glycoprotein hormone over-expressed in many human cancers where it regulates tumor progression and invasion. Evaluating its expression in colorectal cancer and its relation with different clinicopathological parameters can provide valuable information about its role in colorectal cancer progression and behavior. METHODS: This retrospective study was conducted on tissue samples of colorectal cancer. The STC2 immunohistochemical expression was detected and evaluated in 60 cases of colorectal cancer tissue samples of formalin-fixed and paraffin-embedded blocks. Then statistical analysis was performed to assess the relationship between its expression level and several clinicopathological parameters in the studied cases. RESULTS: Statistically significant associations were found between the high level of STC2 immunohistochemical expression and histological tumor grade (P<0.001), tumor depth of invasion (T stage) (P=0.004), lymph node metastasis (N stage) (P=0.001), tumor Dukes’ stage (P<0.001), the presence of lymphovascular invasion (P<0.001), and perineural invasion (P<0.001). CONCLUSION: STC2 over-expression in colorectal cancer may be associated with more aggressive tumor behavior including increased tumor invasion, higher histological grade, higher rate of nodal metastasis and increased incidence of lymphovascular and perineural invasions. These data suggest a potential role for STC2 as a predictive biomarker for tumor behavior in colorectal cancer patients.
format Online
Article
Text
id pubmed-8794563
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Iranian Society of Pathology
record_format MEDLINE/PubMed
spelling pubmed-87945632022-01-29 Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study El hanbuli, Hala M. Galal, Rehab S. Darweesh, Mohammed F. Elmahdi, Mohamed H. Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Colorectal cancer is the third most common cause of cancer death worldwide. Stanniocalcin 2 (STC2) is a glycoprotein hormone over-expressed in many human cancers where it regulates tumor progression and invasion. Evaluating its expression in colorectal cancer and its relation with different clinicopathological parameters can provide valuable information about its role in colorectal cancer progression and behavior. METHODS: This retrospective study was conducted on tissue samples of colorectal cancer. The STC2 immunohistochemical expression was detected and evaluated in 60 cases of colorectal cancer tissue samples of formalin-fixed and paraffin-embedded blocks. Then statistical analysis was performed to assess the relationship between its expression level and several clinicopathological parameters in the studied cases. RESULTS: Statistically significant associations were found between the high level of STC2 immunohistochemical expression and histological tumor grade (P<0.001), tumor depth of invasion (T stage) (P=0.004), lymph node metastasis (N stage) (P=0.001), tumor Dukes’ stage (P<0.001), the presence of lymphovascular invasion (P<0.001), and perineural invasion (P<0.001). CONCLUSION: STC2 over-expression in colorectal cancer may be associated with more aggressive tumor behavior including increased tumor invasion, higher histological grade, higher rate of nodal metastasis and increased incidence of lymphovascular and perineural invasions. These data suggest a potential role for STC2 as a predictive biomarker for tumor behavior in colorectal cancer patients. Iranian Society of Pathology 2022 2021-12-15 /pmc/articles/PMC8794563/ /pubmed/35096084 http://dx.doi.org/10.30699/IJP.2021-.521799.2559 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
El hanbuli, Hala M.
Galal, Rehab S.
Darweesh, Mohammed F.
Elmahdi, Mohamed H.
Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study
title Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study
title_full Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study
title_fullStr Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study
title_full_unstemmed Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study
title_short Immunohistochemical Expression of Stanniocalcin 2 in Colorectal Cancer: A Retrospective Egyptian Study
title_sort immunohistochemical expression of stanniocalcin 2 in colorectal cancer: a retrospective egyptian study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794563/
https://www.ncbi.nlm.nih.gov/pubmed/35096084
http://dx.doi.org/10.30699/IJP.2021-.521799.2559
work_keys_str_mv AT elhanbulihalam immunohistochemicalexpressionofstanniocalcin2incolorectalcanceraretrospectiveegyptianstudy
AT galalrehabs immunohistochemicalexpressionofstanniocalcin2incolorectalcanceraretrospectiveegyptianstudy
AT darweeshmohammedf immunohistochemicalexpressionofstanniocalcin2incolorectalcanceraretrospectiveegyptianstudy
AT elmahdimohamedh immunohistochemicalexpressionofstanniocalcin2incolorectalcanceraretrospectiveegyptianstudy