Synchronous Occurrence of Papillary Thyroid Carcinoma and Medullary Carcinoma in the Setting of Hashimoto’s Thyroiditis and Multi Nodular Goiter

Coexistence of follicular epithelial and bilateral parafollicular cells derivative of carcinomas in the setting of Hashimoto’s thyroiditis and multinodular goiter is a very rare event. Of course, all benign and malignant thyroid lesions are more prevalent in iodine deficient areas. It seems that the context for identifying the pathways influencing thyroid carcinogenesis especially coincidence form has not yet been fully understood and needs further investigation. Here, we present a case with the synchronous occurrence of papillary thyroid carcinoma and medullary thyroid carcinoma in the setting of Hashimoto’s thyroiditis and multinodular goiter. A 54-year-old woman complained of a painless mass in the anterior region of the neck. The physical examination of the patient revealed multiple nodules in her thyroid gland. In ultrasound findings, she presented with thyroid enlargement associated with multiple isoechoic and hypoechoic nodules in both lobes. Thyroid fine needle aspiration results suggested a diagnosis of medullary thyroid carcinoma in the setting of Hashimoto’s thyroiditis and multinodular goiter . The frozen sections, permanent sampling, and IHC examination showed the coexistence of papillary thyroid carcinoma with bilateral medullary thyroid carcinoma in the setting of Hashimoto's disease and multinodular goiter . Studies debated about the risk factors of these pathologies including the same environmental issues or mutations in genomes and they emphasized surgeons should be aware of these lesions for diagnosis and interventional treatments. Following up the Hashimoto’s thyroiditis and multinodular goiter is required for detection ofoccult malignancies, and hence the proper management and treatment should be performed.