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Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions
BACKGROUND & OBJECTIVE: Urine cytology is an important diagnostic method for urinary tract cancers (especially carcinomas), which is suitable for follow-up of residual urothelial tumors after surgery of malignant bladder tumors. Liquid-based cytology (LBC) was used for the first time in cervical...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Pathology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794568/ https://www.ncbi.nlm.nih.gov/pubmed/35096089 http://dx.doi.org/10.30699/IJP.2021.528171.2646 |
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author | Kalantari, Mahmoud Reza Jahanshahi, Mohammad Ali Gharib, Masoumeh Hashemi, Sara Kalantari, Shakiba |
author_facet | Kalantari, Mahmoud Reza Jahanshahi, Mohammad Ali Gharib, Masoumeh Hashemi, Sara Kalantari, Shakiba |
author_sort | Kalantari, Mahmoud Reza |
collection | PubMed |
description | BACKGROUND & OBJECTIVE: Urine cytology is an important diagnostic method for urinary tract cancers (especially carcinomas), which is suitable for follow-up of residual urothelial tumors after surgery of malignant bladder tumors. Liquid-based cytology (LBC) was used for the first time in cervical cytology Compared to direct smear cytology (DSC), LBC reduced background elements (including cellular debris, inflammatory cells, and blood cells), provided better cell preservation, and had a higher satisfaction rate. In this study, we performed two different methods (DSC and LBC) to detect bladder lesions; also, we determined the sensitivity and specificity of these methods. METHODS: A total of 146 samples were taken from patients with suspected bladder cancer and processed for direct smear and LBC. In both methods, findings were reported according to the Paris System. Then, patients underwent cystoscopy and biopsy. Next, the accuracy of cytology methods was evaluated according to biopsy reports. The sensitivity and specificity of these methods were also calculated. RESULTS: Credit indices obtained for the direct smear method included sensitivity (62.5%), specificity (89%), positive predictive value (89.5%), and negative predictive value (91.5%). For LBC methods, credit indices included sensitivity (85.7%), specificity (99%), positive predictive value (96%), and negative predictive value (96%). Agreement between the two methods was statistically significant (P<0.000) in negative biopsies but not in positive biopsies (P>0.05). CONCLUSION: This study showed that LBC has higher sensitivity and specificity than the direct smear. |
format | Online Article Text |
id | pubmed-8794568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Iranian Society of Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-87945682022-01-29 Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions Kalantari, Mahmoud Reza Jahanshahi, Mohammad Ali Gharib, Masoumeh Hashemi, Sara Kalantari, Shakiba Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Urine cytology is an important diagnostic method for urinary tract cancers (especially carcinomas), which is suitable for follow-up of residual urothelial tumors after surgery of malignant bladder tumors. Liquid-based cytology (LBC) was used for the first time in cervical cytology Compared to direct smear cytology (DSC), LBC reduced background elements (including cellular debris, inflammatory cells, and blood cells), provided better cell preservation, and had a higher satisfaction rate. In this study, we performed two different methods (DSC and LBC) to detect bladder lesions; also, we determined the sensitivity and specificity of these methods. METHODS: A total of 146 samples were taken from patients with suspected bladder cancer and processed for direct smear and LBC. In both methods, findings were reported according to the Paris System. Then, patients underwent cystoscopy and biopsy. Next, the accuracy of cytology methods was evaluated according to biopsy reports. The sensitivity and specificity of these methods were also calculated. RESULTS: Credit indices obtained for the direct smear method included sensitivity (62.5%), specificity (89%), positive predictive value (89.5%), and negative predictive value (91.5%). For LBC methods, credit indices included sensitivity (85.7%), specificity (99%), positive predictive value (96%), and negative predictive value (96%). Agreement between the two methods was statistically significant (P<0.000) in negative biopsies but not in positive biopsies (P>0.05). CONCLUSION: This study showed that LBC has higher sensitivity and specificity than the direct smear. Iranian Society of Pathology 2022 2021-11-15 /pmc/articles/PMC8794568/ /pubmed/35096089 http://dx.doi.org/10.30699/IJP.2021.528171.2646 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kalantari, Mahmoud Reza Jahanshahi, Mohammad Ali Gharib, Masoumeh Hashemi, Sara Kalantari, Shakiba Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions |
title | Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions |
title_full | Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions |
title_fullStr | Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions |
title_full_unstemmed | Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions |
title_short | Direct Smear Versus Liquid-Based Cytology in the Diagnosis of Bladder Lesions |
title_sort | direct smear versus liquid-based cytology in the diagnosis of bladder lesions |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794568/ https://www.ncbi.nlm.nih.gov/pubmed/35096089 http://dx.doi.org/10.30699/IJP.2021.528171.2646 |
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