Cargando…

Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions

The development of turbulence after transcatheter aortic valve (TAV) implantation may have detrimental effects on the long-term performance and durability of the valves. The characterization of turbulent flow generated after TAV implantation can provide fundamental insights to enhance implantation t...

Descripción completa

Detalles Bibliográficos
Autores principales: Pietrasanta, Leonardo, Zheng, Shaokai, De Marinis, Dario, Hasler, David, Obrist, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794584/
https://www.ncbi.nlm.nih.gov/pubmed/35097022
http://dx.doi.org/10.3389/fcvm.2021.804565
_version_ 1784640845425672192
author Pietrasanta, Leonardo
Zheng, Shaokai
De Marinis, Dario
Hasler, David
Obrist, Dominik
author_facet Pietrasanta, Leonardo
Zheng, Shaokai
De Marinis, Dario
Hasler, David
Obrist, Dominik
author_sort Pietrasanta, Leonardo
collection PubMed
description The development of turbulence after transcatheter aortic valve (TAV) implantation may have detrimental effects on the long-term performance and durability of the valves. The characterization of turbulent flow generated after TAV implantation can provide fundamental insights to enhance implantation techniques. A self-expandable TAV was tested in a pulse replicator and the three-dimensional flow field was extracted by means of tomographic particle image velocimetry. The valve was fixed inside a silicone phantom mimicking the aortic root and the flow field was studied for two different supra-annular axial positions at peak systole. Fluctuating velocities and turbulent kinetic energy were compared between the two implantations. Velocity spectra were derived at different spatial positions in the turbulent wakes to characterize the turbulent flow. The valve presented similar overall flow topology but approximately 8% higher turbulent intensity in the lower implantation. In this configuration, axial views of the valve revealed smaller opening area and more corrugated leaflets during systole, as well as more accentuated pinwheeling during diastole. The difference arose from a lower degree of expansion of the TAV's stent inside the aortic lumen. These results suggest that the degree of expansion of the TAV in-situ is related to the onset of turbulence and that a smaller and less regular opening area might introduce flow instabilities that could be detrimental for the long-term performance of the valve. The present study highlights how implantation mismatches may affect the structure and intensity of the turbulent flow in the aortic root.
format Online
Article
Text
id pubmed-8794584
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87945842022-01-28 Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions Pietrasanta, Leonardo Zheng, Shaokai De Marinis, Dario Hasler, David Obrist, Dominik Front Cardiovasc Med Cardiovascular Medicine The development of turbulence after transcatheter aortic valve (TAV) implantation may have detrimental effects on the long-term performance and durability of the valves. The characterization of turbulent flow generated after TAV implantation can provide fundamental insights to enhance implantation techniques. A self-expandable TAV was tested in a pulse replicator and the three-dimensional flow field was extracted by means of tomographic particle image velocimetry. The valve was fixed inside a silicone phantom mimicking the aortic root and the flow field was studied for two different supra-annular axial positions at peak systole. Fluctuating velocities and turbulent kinetic energy were compared between the two implantations. Velocity spectra were derived at different spatial positions in the turbulent wakes to characterize the turbulent flow. The valve presented similar overall flow topology but approximately 8% higher turbulent intensity in the lower implantation. In this configuration, axial views of the valve revealed smaller opening area and more corrugated leaflets during systole, as well as more accentuated pinwheeling during diastole. The difference arose from a lower degree of expansion of the TAV's stent inside the aortic lumen. These results suggest that the degree of expansion of the TAV in-situ is related to the onset of turbulence and that a smaller and less regular opening area might introduce flow instabilities that could be detrimental for the long-term performance of the valve. The present study highlights how implantation mismatches may affect the structure and intensity of the turbulent flow in the aortic root. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8794584/ /pubmed/35097022 http://dx.doi.org/10.3389/fcvm.2021.804565 Text en Copyright © 2022 Pietrasanta, Zheng, De Marinis, Hasler and Obrist. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Pietrasanta, Leonardo
Zheng, Shaokai
De Marinis, Dario
Hasler, David
Obrist, Dominik
Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions
title Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions
title_full Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions
title_fullStr Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions
title_full_unstemmed Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions
title_short Characterization of Turbulent Flow Behind a Transcatheter Aortic Valve in Different Implantation Positions
title_sort characterization of turbulent flow behind a transcatheter aortic valve in different implantation positions
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794584/
https://www.ncbi.nlm.nih.gov/pubmed/35097022
http://dx.doi.org/10.3389/fcvm.2021.804565
work_keys_str_mv AT pietrasantaleonardo characterizationofturbulentflowbehindatranscatheteraorticvalveindifferentimplantationpositions
AT zhengshaokai characterizationofturbulentflowbehindatranscatheteraorticvalveindifferentimplantationpositions
AT demarinisdario characterizationofturbulentflowbehindatranscatheteraorticvalveindifferentimplantationpositions
AT haslerdavid characterizationofturbulentflowbehindatranscatheteraorticvalveindifferentimplantationpositions
AT obristdominik characterizationofturbulentflowbehindatranscatheteraorticvalveindifferentimplantationpositions