Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome

BACKGROUND: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous disorder caused by mitochondrial DNA (mtDNA) mutations in the MT-TL1 gene. The pathophysiology of neurological manifestations is still unclear, but neuronal hyperexc...

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Detalles Bibliográficos
Autores principales: Guerrero-Molina, María Paz, Morales-Conejo, Montserrat, Delmiro, Aitor, Morán, María, Domínguez-González, Cristina, Arranz-Canales, Elena, Ramos-González, Ana, Arenas, Joaquín, Martín, Miguel A., González de la Aleja, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794606/
https://www.ncbi.nlm.nih.gov/pubmed/35088140
http://dx.doi.org/10.1007/s00415-021-10942-7

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