Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder

Major depressive disorder (MDD) is associated with increased suicidality, and it’s still challenging to identify suicide in clinical practice. Although suicide attempt (SA) is the most relevant precursor with multiple functional abnormalities reported from neuroimaging studies, little is known about how the spontaneous transient activated patterns organize and coordinate brain networks underlying SA. Thus, we obtained resting-state magnetoencephalography data for two MDD subgroups of 44 non-suicide patients and 34 suicide-attempted patients, together with 49 matched health-controls. For the source-space signals, Hidden Markov Model (HMM) helped to capture the sub-second dynamic activity via a hidden sequence of finite number of states. Temporal parameters and spectral activation were acquired for each state and then compared between groups. Here, HMM states characterized the spatiotemporal signatures of eight networks. The activity of suicide attempters switches more frequently into the fronto-temporal network, as the time spent occupancy of fronto-temporal state is increased and interval time is decreased compared with the non-suicide patients. Moreover, these changes are significantly correlated with Nurses’ Global Assessment of Suicide Risk scores. Suicide attempters also exhibit increased state-wise activations in the theta band (4-8 Hz) in the posterior default mode network centered on posterior cingulate cortex, which can’t be detected in the static spectral analysis. These alternations may disturb the time allocations of cognitive control regulations and cause inflexible decision making to SA. As the better sensitivity of dynamic study in reflecting SA diathesis than the static is validated, dynamic stability could serve as a potential neuronal marker for SA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00406-021-01371-8.