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Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT
Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge. Methods: Between February 2020 and May 2...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794727/ https://www.ncbi.nlm.nih.gov/pubmed/35096849 http://dx.doi.org/10.3389/fmed.2021.686878 |
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author | Liao, Xuejiao Li, Dapeng Liu, Zhi Ma, Zhenghua Zhang, Lina Dong, Jingke Shi, Yirong Gu, Xiaowen Zheng, Guangping Huang, Ling Yuan, Lijun Cao, Jing Shu, Dan Yang, Xiangyi He, Qing Li, Guobao Zhang, Zheng Liu, Lei |
author_facet | Liao, Xuejiao Li, Dapeng Liu, Zhi Ma, Zhenghua Zhang, Lina Dong, Jingke Shi, Yirong Gu, Xiaowen Zheng, Guangping Huang, Ling Yuan, Lijun Cao, Jing Shu, Dan Yang, Xiangyi He, Qing Li, Guobao Zhang, Zheng Liu, Lei |
author_sort | Liao, Xuejiao |
collection | PubMed |
description | Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge. Methods: Between February 2020 and May 2020, a total of 273 patients with COVID-19 at the Shenzhen Third People's Hospital were recruited and followed for 6 months after discharge. Chest CT scanning was performed with the patient in the supine position at end-inspiration. A total of 957 chest CT scans was obtained at different timepoints. A semi-quantitative score was used to assess the degree of lung involvement. Results: Most chest CT scans showed bilateral lung involvement with peripheral location at 3 and 6 months follow-up. The most common CT findings were ground-glass opacity and parenchymal band, which were found in 136 (55.3%) and 94 (38.2%) of the 246 patients at 3 months follow-up, and 82 (48.2%) and 76 (44.7%) of 170 patients at 6 months follow-up, respectively. The number of lobes involved and the total CT severity score declined over time. The total CT score gradually increased with the increasement of disease severity at both 3 months follow-up (trend test P < 0.001) and 6 months follow-up (trend test P < 0.001). Patients with different disease severity represented diverse CT patterns over time. Conclusions: The most common CT findings were ground-glass opacity and parenchymal bands at the 3 and 6 months follow-up. Patients with different disease severity represent diverse CT manifestations, indicating the necessary for long-term follow-up monitoring of patients with severe and critical conditions. |
format | Online Article Text |
id | pubmed-8794727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87947272022-01-28 Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT Liao, Xuejiao Li, Dapeng Liu, Zhi Ma, Zhenghua Zhang, Lina Dong, Jingke Shi, Yirong Gu, Xiaowen Zheng, Guangping Huang, Ling Yuan, Lijun Cao, Jing Shu, Dan Yang, Xiangyi He, Qing Li, Guobao Zhang, Zheng Liu, Lei Front Med (Lausanne) Medicine Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge. Methods: Between February 2020 and May 2020, a total of 273 patients with COVID-19 at the Shenzhen Third People's Hospital were recruited and followed for 6 months after discharge. Chest CT scanning was performed with the patient in the supine position at end-inspiration. A total of 957 chest CT scans was obtained at different timepoints. A semi-quantitative score was used to assess the degree of lung involvement. Results: Most chest CT scans showed bilateral lung involvement with peripheral location at 3 and 6 months follow-up. The most common CT findings were ground-glass opacity and parenchymal band, which were found in 136 (55.3%) and 94 (38.2%) of the 246 patients at 3 months follow-up, and 82 (48.2%) and 76 (44.7%) of 170 patients at 6 months follow-up, respectively. The number of lobes involved and the total CT severity score declined over time. The total CT score gradually increased with the increasement of disease severity at both 3 months follow-up (trend test P < 0.001) and 6 months follow-up (trend test P < 0.001). Patients with different disease severity represented diverse CT patterns over time. Conclusions: The most common CT findings were ground-glass opacity and parenchymal bands at the 3 and 6 months follow-up. Patients with different disease severity represent diverse CT manifestations, indicating the necessary for long-term follow-up monitoring of patients with severe and critical conditions. Frontiers Media S.A. 2022-01-13 /pmc/articles/PMC8794727/ /pubmed/35096849 http://dx.doi.org/10.3389/fmed.2021.686878 Text en Copyright © 2022 Liao, Li, Liu, Ma, Zhang, Dong, Shi, Gu, Zheng, Huang, Yuan, Cao, Shu, Yang, He, Li, Zhang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Liao, Xuejiao Li, Dapeng Liu, Zhi Ma, Zhenghua Zhang, Lina Dong, Jingke Shi, Yirong Gu, Xiaowen Zheng, Guangping Huang, Ling Yuan, Lijun Cao, Jing Shu, Dan Yang, Xiangyi He, Qing Li, Guobao Zhang, Zheng Liu, Lei Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT |
title | Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT |
title_full | Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT |
title_fullStr | Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT |
title_full_unstemmed | Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT |
title_short | Pulmonary Sequelae in Patients After Recovery From Coronavirus Disease 2019: A Follow-Up Study With Chest CT |
title_sort | pulmonary sequelae in patients after recovery from coronavirus disease 2019: a follow-up study with chest ct |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794727/ https://www.ncbi.nlm.nih.gov/pubmed/35096849 http://dx.doi.org/10.3389/fmed.2021.686878 |
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