Cargando…

Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB(1) receptor availability

BACKGROUND: Obesity is a pressing public health concern worldwide. Novel pharmacological means are urgently needed to combat the increase of obesity and accompanying type 2 diabetes (T2D). Although fully established obesity is associated with neuromolecular alterations and insulin resistance in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kantonen, Tatu, Pekkarinen, Laura, Karjalainen, Tomi, Bucci, Marco, Kalliokoski, Kari, Haaparanta-Solin, Merja, Aarnio, Richard, Dickens, Alex M., von Eyken, Annie, Laitinen, Kirsi, Houttu, Noora, Kirjavainen, Anna K., Helin, Semi, Hirvonen, Jussi, Rönnemaa, Tapani, Nuutila, Pirjo, Nummenmaa, Lauri
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794779/ https://www.ncbi.nlm.nih.gov/pubmed/34728775 http://dx.doi.org/10.1038/s41366-021-00996-y

Ejemplares similares

Obesity risk is associated with brain glucose uptake and insulin resistance
por: Pekkarinen, Laura, et al.
Publicado: (2022)

Cerebral μ-opioid and CB(1) receptor systems have distinct roles in human feeding behavior
por: Kantonen, Tatu, et al.
Publicado: (2021)

Association of CNR1 gene and cannabinoid 1 receptor protein in the human brain
por: Pak, Kyoungjune, et al.
Publicado: (2022)

Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety
por: Nummenmaa, Lauri, et al.
Publicado: (2020)

Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
por: Lahdenpohja, Salla, et al.
Publicado: (2020)

Seasonal Variation in the Brain μ-Opioid Receptor Availability
por: Sun, Lihua, et al.
Publicado: (2021)

μ-opioid receptor availability is associated with sex drive in human males
por: Nummenmaa, Lauri, et al.
Publicado: (2021)

Magia: Robust Automated Image Processing and Kinetic Modeling Toolbox for PET Neuroinformatics
por: Karjalainen, Tomi, et al.
Publicado: (2020)

Preoperative brain μ-opioid receptor availability predicts weight development following bariatric surgery in women
por: Karlsson, Henry K., et al.
Publicado: (2021)

Mesolimbic opioid-dopamine interaction is disrupted in obesity but recovered by weight loss following bariatric surgery
por: Karlsson, Henry K., et al.
Publicado: (2021)

μ-opioid receptor system mediates reward processing in humans
por: Nummenmaa, Lauri, et al.
Publicado: (2018)

Increased Brain Fatty Acid Uptake in Metabolic Syndrome
por: Karmi, Anna, et al.
Publicado: (2010)

Direct Comparison of [(18)F]F-DPA with [(18)F]DPA-714 and [(11)C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls
por: López-Picón, Francisco R., et al.
Publicado: (2021)

Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults
por: Raiko, Juho R. H., et al.
Publicado: (2021)

In vivo characterization of a novel norepinephrine transporter PET tracer [(18)F]NS12137 in adult and immature Sprague-Dawley rats
por: López-Picón, Francisco R., et al.
Publicado: (2019)

Brain free fatty acid uptake is elevated in morbid obesity, and is irreversible 6 months after bariatric surgery: A positron emission tomography study
por: Rebelos, Eleni, et al.
Publicado: (2020)

Neural Circuits for Cognitive Appetite Control in Healthy and Obese Individuals: An fMRI Study
por: Tuulari, Jetro J., et al.
Publicado: (2015)

The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the Aβ Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay
por: Pihlaja, Rea, et al.
Publicado: (2017)

Dorsal Striatum and Its Limbic Connectivity Mediate Abnormal Anticipatory Reward Processing in Obesity
por: Nummenmaa, Lauri, et al.
Publicado: (2012)

Two weeks of moderate-intensity continuous training, but not high-intensity interval training, increases insulin-stimulated intestinal glucose uptake
por: Motiani, Kumail K., et al.
Publicado: (2017)

[(11)C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue
por: Sun, Lihua, et al.
Publicado: (2022)

Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort
por: Rebelos, Eleni, et al.
Publicado: (2021)

Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation
por: Vainio, S. K., et al.
Publicado: (2022)

Radiosynthesis and Preclinical Evaluation of [(18)F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats
por: Keller, Thomas, et al.
Publicado: (2017)

Enzyme inhibition of dopamine metabolism alters 6-[(18)F]FDOPA uptake in orthotopic pancreatic adenocarcinoma
por: Tuomela, Johanna, et al.
Publicado: (2013)

Corrigendum to “Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women” [Heliyon 6 (8) (August 2020) Article e04788]
por: Mokkala, Kati, et al.
Publicado: (2020)

Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women
por: Mokkala, Kati, et al.
Publicado: (2020)

Regulation of human brown adipose tissue by adenosine and A(2A) receptors – studies with [(15)O]H(2)O and [(11)C]TMSX PET/CT
por: Lahesmaa, Minna, et al.
Publicado: (2018)

Endogenous Opioid Release After Orgasm in Man: A Combined PET/Functional MRI Study
por: Jern, Patrick, et al.
Publicado: (2023)

Effect of genotype and age on cerebral [(18)F]FDG uptake varies between transgenic APP(Swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer’s disease
por: Snellman, Anniina, et al.
Publicado: (2019)

Ventilation during continuous compressions or at 30:2 compression-to-ventilation ratio results in similar arterial oxygen and carbon dioxide levels in an experimental model of prolonged cardiac arrest
por: Kopra, Jukka, et al.
Publicado: (2023)

Brain insulin sensitivity is linked to body fat distribution—the positron emission tomography perspective
por: Rebelos, Eleni, et al.
Publicado: (2020)

Neural responses to biological motion distinguish autistic and schizotypal traits
por: Hudson, Matthew, et al.
Publicado: (2023)

Impact of combined consumption of fish oil and probiotics on the serum metabolome in pregnant women with overweight or obesity
por: Mokkala, Kati, et al.
Publicado: (2021)

[(18)F]SPA-RQ/PET Study of NK1 receptors in the Whole Body of Guinea Pig and Rat
por: Grönroos, Tove J., et al.
Publicado: (2019)

[(18)F]Fluoride uptake in various bone types and soft tissues in rat
por: Savisto, Nina, et al.
Publicado: (2023)

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
por: Bonvicini, Gillian, et al.
Publicado: (2022)

GlycA, a novel marker for low grade inflammation, reflects gut microbiome diversity and is more accurate than high sensitive CRP in reflecting metabolomic profile
por: Mokkala, Kati, et al.
Publicado: (2020)

[(18)F]CFT synthesis and binding to monoamine transporters in rats
por: Forsback, Sarita, et al.
Publicado: (2012)

The Impacts of Fish Oil and/or Probiotic Intervention on Low-Grade Inflammation, IGFBP-1 and MMP-8 in Pregnancy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
por: Houttu, Noora, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0sq1mag33u3svf22f5mpflcjte