Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing

HIV-1 infection produces a long-lived reservoir of latently infected CD4(+) T cells that represents the major barrier to HIV-1 cure. The reservoir contains both intact and defective proviruses, but only the proviruses that are intact can reinitiate infection upon cessation of antiretroviral therapy...

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Detalles Bibliográficos
Autores principales: Cho, Alice, Gaebler, Christian, Olveira, Thiago, Ramos, Victor, Saad, Marwa, Lorenzi, Julio C. C., Gazumyan, Anna, Moir, Susan, Caskey, Marina, Chun, Tae-Wook, Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794825/
https://www.ncbi.nlm.nih.gov/pubmed/35042816
http://dx.doi.org/10.1073/pnas.2117630119

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