Cargando…
Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial
OBJECTIVES: To evaluate the correlation between liver enhancement on hepatobiliary phase and liver function parameters in a multicenter, multivendor study. METHODS: A total of 359 patients who underwent gadoxetic acid–enhanced MRI using a standardized protocol with various scanners within a prospect...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795026/ https://www.ncbi.nlm.nih.gov/pubmed/34467453 http://dx.doi.org/10.1007/s00330-021-08218-9 |
_version_ | 1784640956454141952 |
---|---|
author | Öcal, Osman Peynircioglu, Bora Loewe, Christian van Delden, Otto Vandecaveye, Vincent Gebauer, Bernhard Zech, Christoph J. Sengel, Christian Bargellini, Irene Iezzi, Roberto Benito, Alberto Schütte, Kerstin Gasbarrini, Antonio Seidensticker, Ricarda Wildgruber, Moritz Pech, Maciej Malfertheiner, Peter Ricke, Jens Seidensticker, Max |
author_facet | Öcal, Osman Peynircioglu, Bora Loewe, Christian van Delden, Otto Vandecaveye, Vincent Gebauer, Bernhard Zech, Christoph J. Sengel, Christian Bargellini, Irene Iezzi, Roberto Benito, Alberto Schütte, Kerstin Gasbarrini, Antonio Seidensticker, Ricarda Wildgruber, Moritz Pech, Maciej Malfertheiner, Peter Ricke, Jens Seidensticker, Max |
author_sort | Öcal, Osman |
collection | PubMed |
description | OBJECTIVES: To evaluate the correlation between liver enhancement on hepatobiliary phase and liver function parameters in a multicenter, multivendor study. METHODS: A total of 359 patients who underwent gadoxetic acid–enhanced MRI using a standardized protocol with various scanners within a prospective multicenter phase II trial (SORAMIC) were evaluated. The correlation between liver enhancement on hepatobiliary phase normalized to the spleen (liver-to-spleen ratio, LSR) and biochemical laboratory parameters, clinical findings related to liver functions, liver function grading systems (Child-Pugh and Albumin-Bilirubin [ALBI]), and scanner characteristics were analyzed using uni- and multivariate analyses. RESULTS: There was a significant positive correlation between LSR and albumin (rho = 0.193; p < 0.001), platelet counts (rho = 0.148; p = 0.004), and sodium (rho = 0.161; p = 0.002); and a negative correlation between LSR and total bilirubin (rho = −0.215; p < 0.001) and AST (rho = −0.191; p < 0.001). Multivariate analysis confirmed independent significance for each of albumin (p = 0.022), total bilirubin (p = 0.045), AST (p = 0.031), platelet counts (p = 0.012), and sodium (p = 0.006). The presence of ascites (1.47 vs. 1.69, p < 0.001) and varices (1.55 vs. 1.69, p = 0.006) was related to significantly lower LSR. Similarly, patients with ALBI grade 1 had significantly higher LSR than patients with grade 2 (1.74 ± 0.447 vs. 1.56 ± 0.408, p < 0.001); and Child-Pugh A patients had a significantly higher LSR than Child-Pugh B (1.67 ± 0.44 vs. 1.49 ± 0.33, p = 0.021). Also, LSR was negatively correlated with MELD-Na scores (rho = −0.137; p = 0.013). However, one scanner brand was significantly associated with lower LSR (p < 0.001). CONCLUSIONS: The liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI is correlated with biomarkers of liver functions in a multicenter cohort. However, this correlation shows variations between scanner brands. KEY POINTS: • The correlation between liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI and liver function is consistent in a multicenter-multivendor cohort. • Signal intensity–based indices (liver-to-spleen ratio) can be used as an imaging biomarker of liver function. • However, absolute values might change between vendors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00330-021-08218-9. |
format | Online Article Text |
id | pubmed-8795026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-87950262022-02-02 Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial Öcal, Osman Peynircioglu, Bora Loewe, Christian van Delden, Otto Vandecaveye, Vincent Gebauer, Bernhard Zech, Christoph J. Sengel, Christian Bargellini, Irene Iezzi, Roberto Benito, Alberto Schütte, Kerstin Gasbarrini, Antonio Seidensticker, Ricarda Wildgruber, Moritz Pech, Maciej Malfertheiner, Peter Ricke, Jens Seidensticker, Max Eur Radiol Magnetic Resonance OBJECTIVES: To evaluate the correlation between liver enhancement on hepatobiliary phase and liver function parameters in a multicenter, multivendor study. METHODS: A total of 359 patients who underwent gadoxetic acid–enhanced MRI using a standardized protocol with various scanners within a prospective multicenter phase II trial (SORAMIC) were evaluated. The correlation between liver enhancement on hepatobiliary phase normalized to the spleen (liver-to-spleen ratio, LSR) and biochemical laboratory parameters, clinical findings related to liver functions, liver function grading systems (Child-Pugh and Albumin-Bilirubin [ALBI]), and scanner characteristics were analyzed using uni- and multivariate analyses. RESULTS: There was a significant positive correlation between LSR and albumin (rho = 0.193; p < 0.001), platelet counts (rho = 0.148; p = 0.004), and sodium (rho = 0.161; p = 0.002); and a negative correlation between LSR and total bilirubin (rho = −0.215; p < 0.001) and AST (rho = −0.191; p < 0.001). Multivariate analysis confirmed independent significance for each of albumin (p = 0.022), total bilirubin (p = 0.045), AST (p = 0.031), platelet counts (p = 0.012), and sodium (p = 0.006). The presence of ascites (1.47 vs. 1.69, p < 0.001) and varices (1.55 vs. 1.69, p = 0.006) was related to significantly lower LSR. Similarly, patients with ALBI grade 1 had significantly higher LSR than patients with grade 2 (1.74 ± 0.447 vs. 1.56 ± 0.408, p < 0.001); and Child-Pugh A patients had a significantly higher LSR than Child-Pugh B (1.67 ± 0.44 vs. 1.49 ± 0.33, p = 0.021). Also, LSR was negatively correlated with MELD-Na scores (rho = −0.137; p = 0.013). However, one scanner brand was significantly associated with lower LSR (p < 0.001). CONCLUSIONS: The liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI is correlated with biomarkers of liver functions in a multicenter cohort. However, this correlation shows variations between scanner brands. KEY POINTS: • The correlation between liver enhancement on the hepatobiliary phase of gadoxetic acid–enhanced MRI and liver function is consistent in a multicenter-multivendor cohort. • Signal intensity–based indices (liver-to-spleen ratio) can be used as an imaging biomarker of liver function. • However, absolute values might change between vendors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00330-021-08218-9. Springer Berlin Heidelberg 2021-08-31 2022 /pmc/articles/PMC8795026/ /pubmed/34467453 http://dx.doi.org/10.1007/s00330-021-08218-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Magnetic Resonance Öcal, Osman Peynircioglu, Bora Loewe, Christian van Delden, Otto Vandecaveye, Vincent Gebauer, Bernhard Zech, Christoph J. Sengel, Christian Bargellini, Irene Iezzi, Roberto Benito, Alberto Schütte, Kerstin Gasbarrini, Antonio Seidensticker, Ricarda Wildgruber, Moritz Pech, Maciej Malfertheiner, Peter Ricke, Jens Seidensticker, Max Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial |
title | Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial |
title_full | Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial |
title_fullStr | Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial |
title_full_unstemmed | Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial |
title_short | Correlation of liver enhancement in gadoxetic acid–enhanced MRI with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial |
title_sort | correlation of liver enhancement in gadoxetic acid–enhanced mri with liver functions: a multicenter-multivendor analysis of hepatocellular carcinoma patients from soramic trial |
topic | Magnetic Resonance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795026/ https://www.ncbi.nlm.nih.gov/pubmed/34467453 http://dx.doi.org/10.1007/s00330-021-08218-9 |
work_keys_str_mv | AT ocalosman correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT peynircioglubora correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT loewechristian correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT vandeldenotto correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT vandecaveyevincent correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT gebauerbernhard correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT zechchristophj correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT sengelchristian correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT bargelliniirene correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT iezziroberto correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT benitoalberto correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT schuttekerstin correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT gasbarriniantonio correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT seidenstickerricarda correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT wildgrubermoritz correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT pechmaciej correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT malfertheinerpeter correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT rickejens correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial AT seidenstickermax correlationofliverenhancementingadoxeticacidenhancedmriwithliverfunctionsamulticentermultivendoranalysisofhepatocellularcarcinomapatientsfromsoramictrial |