Diabetic Kidney Disease is Associated with Increased Complications Following Operative Management of Ankle Fractures

CATEGORY: Trauma; Ankle; Diabetes INTRODUCTION/PURPOSE: Diabetes mellitus and peripheral neuropathy are established risk factors for complications in operatively treated ankle fractures. Generally, the presence of peripheral neuropathy and diabetic nephropathy have been used as dependent variables in studies of diabetic ankle fracture cohorts, but these factors are typically treated as binary risk factors. Thus, we sought to quantify additional risk factors for complication specific to diabetic patients undergoing fracture fixation. METHODS: We identified 617 rotational ankle fractures treated operatively at a single academic medical center from 2010-2019, of which 160 were identified as diabetic. Of these, 91 ankle fractures in 90 diabetic patients met criteria for retrospective review of clinical and radiographic data. Criteria included perioperative laboratory studies, including Hemoglobin A1c and estimated glomerular filtration rate (eGFR), as well as follow-up radiographs in the electronic record. We defined complications in this surgical cohort as deep surgical site infection, unplanned return to the OR and failure of fixation. Logistic regression was performed, and odds ratios (OR) calculated. RESULTS: The overall the complication rate was 24.2% (22/91) in this cohort. Median follow-up was 29 weeks (range: 5-520 weeks). Mean perioperative Hemoglobin A1c in patients who experienced postoperative complications was 7.6% (Range: 5.1%- 14.2%) compared to 7.8% (Range:5.6%-13.5%) who did not (p=0.69). Diabetic patients with chronic kidney disease (eGFR<60 ml/min/BSA) (OR=5.29, p=0.006) and peripheral neuropathy (OR=4.61, p=0.003) were at significantly higher risk of all complications compared to diabetic patients without these comorbidities. Of note, we did not find an association between perioperative Hemoglobin A1c or Body Mass Index and complication rate. CONCLUSION: Patients with diabetes complicated by chronic kidney disease are at significantly higher risk of complications following operative management of ankle fractures. Our study also corroborated previous reports that within this high-risk cohort, the presence of peripheral neuropathy is a significant risk factor for complications. These sequalae of diabetic disease extends beyond simple glycemic and are manifestations of microvascular disease, glycosylation of soft tissues and impaired metabolic pathways. Identifying these risk factors in diabetic patients allows for patient specific risk stratification, education, and management decisions of ankle fractures.