Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study

Obstructive sleep apnea (OSA) is a common disorder associated with increased risk of cardiovascular disease and mortality. Iron and heme metabolism, implicated in ventilatory control and OSA comorbidities, was associated with OSA phenotypes in recent admixture mapping and gene enrichment analyses. H...

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Detalles Bibliográficos
Autores principales: Wang, Heming, Kurniansyah, Nuzulul, Cade, Brian E., Goodman, Matthew O., Chen, Han, Gottlieb, Daniel J., Gharib, Sina A., Purcell, Shaun M., Lin, Xihong, Saxena, Richa, Zhu, Xiaofeng, Durda, Peter, Tracy, Russel, Liu, Yongmei, Taylor, Kent D., Johnson, W. Craig, Gabriel, Stacey, Smith, Joshua D., Aguet, François, Ardlie, Kirstin, Blackwell, Tom, Reiner, Alexander P., Rotter, Jerome I., Rich, Stephen S., Redline, Susan, Sofer, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795126/
https://www.ncbi.nlm.nih.gov/pubmed/35087136
http://dx.doi.org/10.1038/s41598-022-05415-4

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