Machine learning-based approaches for identifying human blood cells harboring CRISPR-mediated fetal chromatin domain ablations

Two common hemoglobinopathies, sickle cell disease (SCD) and β-thalassemia, arise from genetic mutations within the β-globin gene. In this work, we identified a 500-bp motif (Fetal Chromatin Domain, FCD) upstream of human ϒ-globin locus and showed that the removal of this motif using CRISPR technolo...

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Detalles Bibliográficos
Autores principales: Li, Yi, Zaheri, Shadi, Nguyen, Khai, Liu, Li, Hassanipour, Fatemeh, Bleris, Leonidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795181/
https://www.ncbi.nlm.nih.gov/pubmed/35087158
http://dx.doi.org/10.1038/s41598-022-05575-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795181/
https://www.ncbi.nlm.nih.gov/pubmed/35087158
http://dx.doi.org/10.1038/s41598-022-05575-3

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