Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not

Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS an...

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Autores principales: Frank, Anika, Bendig, Jonas, Schniewind, Iñaki, Polanski, Witold H., Sobottka, Stephan B., Reichmann, Heinz, Akgün, Katja, Ziemssen, Tjalf, Klingelhoefer, Lisa, Falkenburger, Björn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795190/
https://www.ncbi.nlm.nih.gov/pubmed/35087088
http://dx.doi.org/10.1038/s41598-022-05117-x
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author Frank, Anika
Bendig, Jonas
Schniewind, Iñaki
Polanski, Witold H.
Sobottka, Stephan B.
Reichmann, Heinz
Akgün, Katja
Ziemssen, Tjalf
Klingelhoefer, Lisa
Falkenburger, Björn H.
author_facet Frank, Anika
Bendig, Jonas
Schniewind, Iñaki
Polanski, Witold H.
Sobottka, Stephan B.
Reichmann, Heinz
Akgün, Katja
Ziemssen, Tjalf
Klingelhoefer, Lisa
Falkenburger, Björn H.
author_sort Frank, Anika
collection PubMed
description Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
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spelling pubmed-87951902022-01-28 Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not Frank, Anika Bendig, Jonas Schniewind, Iñaki Polanski, Witold H. Sobottka, Stephan B. Reichmann, Heinz Akgün, Katja Ziemssen, Tjalf Klingelhoefer, Lisa Falkenburger, Björn H. Sci Rep Article Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not. Nature Publishing Group UK 2022-01-27 /pmc/articles/PMC8795190/ /pubmed/35087088 http://dx.doi.org/10.1038/s41598-022-05117-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Frank, Anika
Bendig, Jonas
Schniewind, Iñaki
Polanski, Witold H.
Sobottka, Stephan B.
Reichmann, Heinz
Akgün, Katja
Ziemssen, Tjalf
Klingelhoefer, Lisa
Falkenburger, Björn H.
Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
title Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
title_full Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
title_fullStr Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
title_full_unstemmed Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
title_short Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not
title_sort serum neurofilament indicates that dbs surgery can cause neuronal damage whereas stimulation itself does not
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795190/
https://www.ncbi.nlm.nih.gov/pubmed/35087088
http://dx.doi.org/10.1038/s41598-022-05117-x
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