The ins and outs of SARS-CoV-2 variants of concern (VOCs)

SARS-CoV-2, a newly emerging coronavirus that caused the COVID-19 epidemic, has been spreading quickly throughout the world. Despite immunization and some fairly effective therapeutic regimens, SARS-CoV-2 has been ravaging patients, health workers, and the economy. SARS-CoV-2 mutates and evolves to...

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Autores principales: Salehi-Vaziri, Mostafa, Fazlalipour, Mehdi, Seyed Khorrami, Seyed Mahmood, Azadmanesh, Kayhan, Pouriayevali, Mohammad Hassan, Jalali, Tahmineh, Shoja, Zabihollah, Maleki, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795292/
https://www.ncbi.nlm.nih.gov/pubmed/35089389
http://dx.doi.org/10.1007/s00705-022-05365-2
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author Salehi-Vaziri, Mostafa
Fazlalipour, Mehdi
Seyed Khorrami, Seyed Mahmood
Azadmanesh, Kayhan
Pouriayevali, Mohammad Hassan
Jalali, Tahmineh
Shoja, Zabihollah
Maleki, Ali
author_facet Salehi-Vaziri, Mostafa
Fazlalipour, Mehdi
Seyed Khorrami, Seyed Mahmood
Azadmanesh, Kayhan
Pouriayevali, Mohammad Hassan
Jalali, Tahmineh
Shoja, Zabihollah
Maleki, Ali
author_sort Salehi-Vaziri, Mostafa
collection PubMed
description SARS-CoV-2, a newly emerging coronavirus that caused the COVID-19 epidemic, has been spreading quickly throughout the world. Despite immunization and some fairly effective therapeutic regimens, SARS-CoV-2 has been ravaging patients, health workers, and the economy. SARS-CoV-2 mutates and evolves to adapt to its host as a result of extreme selection pressure. As a consequence, new SARS-CoV-2 variants have emerged, some of which are classified as variants of concern (VOC) because they exhibit greater transmissibility, cause more-severe disease, are better able to escape immunity, or cause higher mortality than the original Wuhan strain. Here, we introduce these VOCs and review their characteristics, such as transmissibility, immune escape, mortality risk, and diagnostics.
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spelling pubmed-87952922022-01-28 The ins and outs of SARS-CoV-2 variants of concern (VOCs) Salehi-Vaziri, Mostafa Fazlalipour, Mehdi Seyed Khorrami, Seyed Mahmood Azadmanesh, Kayhan Pouriayevali, Mohammad Hassan Jalali, Tahmineh Shoja, Zabihollah Maleki, Ali Arch Virol Review SARS-CoV-2, a newly emerging coronavirus that caused the COVID-19 epidemic, has been spreading quickly throughout the world. Despite immunization and some fairly effective therapeutic regimens, SARS-CoV-2 has been ravaging patients, health workers, and the economy. SARS-CoV-2 mutates and evolves to adapt to its host as a result of extreme selection pressure. As a consequence, new SARS-CoV-2 variants have emerged, some of which are classified as variants of concern (VOC) because they exhibit greater transmissibility, cause more-severe disease, are better able to escape immunity, or cause higher mortality than the original Wuhan strain. Here, we introduce these VOCs and review their characteristics, such as transmissibility, immune escape, mortality risk, and diagnostics. Springer Vienna 2022-01-28 2022 /pmc/articles/PMC8795292/ /pubmed/35089389 http://dx.doi.org/10.1007/s00705-022-05365-2 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Salehi-Vaziri, Mostafa
Fazlalipour, Mehdi
Seyed Khorrami, Seyed Mahmood
Azadmanesh, Kayhan
Pouriayevali, Mohammad Hassan
Jalali, Tahmineh
Shoja, Zabihollah
Maleki, Ali
The ins and outs of SARS-CoV-2 variants of concern (VOCs)
title The ins and outs of SARS-CoV-2 variants of concern (VOCs)
title_full The ins and outs of SARS-CoV-2 variants of concern (VOCs)
title_fullStr The ins and outs of SARS-CoV-2 variants of concern (VOCs)
title_full_unstemmed The ins and outs of SARS-CoV-2 variants of concern (VOCs)
title_short The ins and outs of SARS-CoV-2 variants of concern (VOCs)
title_sort ins and outs of sars-cov-2 variants of concern (vocs)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795292/
https://www.ncbi.nlm.nih.gov/pubmed/35089389
http://dx.doi.org/10.1007/s00705-022-05365-2
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