Cargando…

Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy

OBJECTIVE: To investigate the association between foveal outer nuclear layer (ONL) thickness and the natural course of central serous chorioretinopathy (CSC), as well as the thickness change after photodynamic therapy (PDT), exploring the PDT timing for CSC. METHODS: This retrospective consecutive c...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Kaixin, Gui, Yufei, Cai, Yi, Liang, Zhiqiao, Shi, Xuan, Sun, Yaoyao, Zhao, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795370/
https://www.ncbi.nlm.nih.gov/pubmed/35096914
http://dx.doi.org/10.3389/fmed.2021.824239
_version_ 1784641053883629568
author Deng, Kaixin
Gui, Yufei
Cai, Yi
Liang, Zhiqiao
Shi, Xuan
Sun, Yaoyao
Zhao, Mingwei
author_facet Deng, Kaixin
Gui, Yufei
Cai, Yi
Liang, Zhiqiao
Shi, Xuan
Sun, Yaoyao
Zhao, Mingwei
author_sort Deng, Kaixin
collection PubMed
description OBJECTIVE: To investigate the association between foveal outer nuclear layer (ONL) thickness and the natural course of central serous chorioretinopathy (CSC), as well as the thickness change after photodynamic therapy (PDT), exploring the PDT timing for CSC. METHODS: This retrospective consecutive case series included 358 CSC patients between January 2014 and December 2019. All patients were divided into four groups depending on disease duration: Group A: ≤1 month; Group B: >1 and ≤3 months; Group C: >3 and≤6 months and Group D: >6 months. Foveal ONL thickness of the CSC eye and the clinically healthy fellow eye were measured and compared in all patients. Fifty-six patients were successfully treated with half-dose of PDT, showing complete subretinal fluid absorption, were followed up for more than 6 months and further investigated. The recovery of foveal ONL thickness was analyzed in the affected eyes of patients with different disease duration. RESULTS: No significant reduction was found in CSC foveal ONL thickness (μm) compared to the fellow eye in patients with disease duration less than 1 week (112.3 ± 12.2 vs. 116.7 ± 15.3, P = 0.268). Patients with longer disease duration had varying degrees of ONL thinning compared to the contralateral eye (all P < 0.05) and this difference was more pronounced in patients with disease duration greater than 6 months (75.8 ± 12.9 vs. 113.0 ± 11.5, P < 0.001). At 6-month follow-up after PDT, foveal ONL thickness of patients with <1 month disease duration recovered significantly from onset (97.3 ± 18.2 to 113.6 ± 8.7, P < 0.001) and became similar to that of the healthy fellow eye. Foveal ONL thickness of patients with duration>1 and≤3 months recovered significantly (88.5 ± 11.5 to 95.8 ± 11.3, P = 0.012) but remained thinner than that of the healthy fellow eye. Foveal ONL thickness did not improve significantly in cases with disease duration longer than 3 months (P > 0.05). CONCLUSION: Foveal ONL thinning was positively associated with disease duration prior to treatment suggesting that longer disease duration limits scope for foveal ONL recovery. CSC patients should be treated with PDT as soon as possible to prevent disease development and reduced visual function.
format Online
Article
Text
id pubmed-8795370
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87953702022-01-29 Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy Deng, Kaixin Gui, Yufei Cai, Yi Liang, Zhiqiao Shi, Xuan Sun, Yaoyao Zhao, Mingwei Front Med (Lausanne) Medicine OBJECTIVE: To investigate the association between foveal outer nuclear layer (ONL) thickness and the natural course of central serous chorioretinopathy (CSC), as well as the thickness change after photodynamic therapy (PDT), exploring the PDT timing for CSC. METHODS: This retrospective consecutive case series included 358 CSC patients between January 2014 and December 2019. All patients were divided into four groups depending on disease duration: Group A: ≤1 month; Group B: >1 and ≤3 months; Group C: >3 and≤6 months and Group D: >6 months. Foveal ONL thickness of the CSC eye and the clinically healthy fellow eye were measured and compared in all patients. Fifty-six patients were successfully treated with half-dose of PDT, showing complete subretinal fluid absorption, were followed up for more than 6 months and further investigated. The recovery of foveal ONL thickness was analyzed in the affected eyes of patients with different disease duration. RESULTS: No significant reduction was found in CSC foveal ONL thickness (μm) compared to the fellow eye in patients with disease duration less than 1 week (112.3 ± 12.2 vs. 116.7 ± 15.3, P = 0.268). Patients with longer disease duration had varying degrees of ONL thinning compared to the contralateral eye (all P < 0.05) and this difference was more pronounced in patients with disease duration greater than 6 months (75.8 ± 12.9 vs. 113.0 ± 11.5, P < 0.001). At 6-month follow-up after PDT, foveal ONL thickness of patients with <1 month disease duration recovered significantly from onset (97.3 ± 18.2 to 113.6 ± 8.7, P < 0.001) and became similar to that of the healthy fellow eye. Foveal ONL thickness of patients with duration>1 and≤3 months recovered significantly (88.5 ± 11.5 to 95.8 ± 11.3, P = 0.012) but remained thinner than that of the healthy fellow eye. Foveal ONL thickness did not improve significantly in cases with disease duration longer than 3 months (P > 0.05). CONCLUSION: Foveal ONL thinning was positively associated with disease duration prior to treatment suggesting that longer disease duration limits scope for foveal ONL recovery. CSC patients should be treated with PDT as soon as possible to prevent disease development and reduced visual function. Frontiers Media S.A. 2022-01-14 /pmc/articles/PMC8795370/ /pubmed/35096914 http://dx.doi.org/10.3389/fmed.2021.824239 Text en Copyright © 2022 Deng, Gui, Cai, Liang, Shi, Sun and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Deng, Kaixin
Gui, Yufei
Cai, Yi
Liang, Zhiqiao
Shi, Xuan
Sun, Yaoyao
Zhao, Mingwei
Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
title Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
title_full Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
title_fullStr Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
title_full_unstemmed Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
title_short Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
title_sort changes in the foveal outer nuclear layer of central serous chorioretinopathy patients over the disease course and their response to photodynamic therapy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795370/
https://www.ncbi.nlm.nih.gov/pubmed/35096914
http://dx.doi.org/10.3389/fmed.2021.824239
work_keys_str_mv AT dengkaixin changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy
AT guiyufei changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy
AT caiyi changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy
AT liangzhiqiao changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy
AT shixuan changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy
AT sunyaoyao changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy
AT zhaomingwei changesinthefovealouternuclearlayerofcentralserouschorioretinopathypatientsoverthediseasecourseandtheirresponsetophotodynamictherapy