Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways

The kinetics of amyloid beta turnover within human brain is still poorly understood. We previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not known if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) fluid exchange, CSF turnover, blood-brain barrier fun...

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Detalles Bibliográficos
Autores principales: Elbert, Donald L., Patterson, Bruce W., Lucey, Brendan P., Benzinger, Tammie L. S., Bateman, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795390/
https://www.ncbi.nlm.nih.gov/pubmed/35087179
http://dx.doi.org/10.1038/s42003-022-03037-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795390/
https://www.ncbi.nlm.nih.gov/pubmed/35087179
http://dx.doi.org/10.1038/s42003-022-03037-0

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