Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

Antibiotic persistence describes the presence of phenotypic variants within an isogenic bacterial population that are transiently tolerant to antibiotic treatment. Perturbations of metabolic homeostasis can promote antibiotic persistence, but the precise mechanisms are not well understood. Here, we...

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Detalles Bibliográficos
Autores principales: Van den Bergh, Bram, Schramke, Hannah, Michiels, Joran Elie, Kimkes, Tom E. P., Radzikowski, Jakub Leszek, Schimpf, Johannes, Vedelaar, Silke R., Burschel, Sabrina, Dewachter, Liselot, Lončar, Nikola, Schmidt, Alexander, Meijer, Tim, Fauvart, Maarten, Friedrich, Thorsten, Michiels, Jan, Heinemann, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795404/
https://www.ncbi.nlm.nih.gov/pubmed/35087069
http://dx.doi.org/10.1038/s41467-022-28141-x

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