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Viral immune evasins impact antigen presentation by allele-specific trapping of MHC I at the peptide-loading complex

Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells to eliminate infected or cancerous cells. The transporter associated with antigen processing (TAP) shuttles proteasomally generated peptides into the ER for MHC I loading. As central part of th...

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Detalles Bibliográficos
Autores principales:	Sethumadhavan, Sunesh, Barth, Marie, Spaapen, Robbert M., Schmidt, Carla, Trowitzsch, Simon, Tampé, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795405/ https://www.ncbi.nlm.nih.gov/pubmed/35087068 http://dx.doi.org/10.1038/s41598-022-05000-9

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