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Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease

The third isoform of the Na(+)–Ca(2+) exchanger (NCX3) is crucial for a physiological fine-tuning of the Ca(2+) fluxes in excitable tissues. In this view, the NCX3 accounts for the aberrant Ca(2+) influx seen during neuronal excitotoxicity, such as in Alzheimer’s disease (AD). However, little is kno...

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Detalles Bibliográficos
Autores principales:	Afewerky, Henok Kessete, Li, Hao, Zhang, Tongmei, Li, Xinyan, Mahaman, Yacoubou Abdoul Razak, Duan, Limin, Qin, Pengwei, Zheng, Jiequn, Pei, Lei, Lu, Youming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795410/ https://www.ncbi.nlm.nih.gov/pubmed/35087161 http://dx.doi.org/10.1038/s41598-022-05568-2

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