GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation

G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes. However, the impact of individual GRKs on arrestin binding is not clear. We report the creation of eleven combinatorial H...

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Detalles Bibliográficos
Autores principales: Drube, J., Haider, R. S., Matthees, E. S. F., Reichel, M., Zeiner, J., Fritzwanker, S., Ziegler, C., Barz, S., Klement, L., Filor, J., Weitzel, V., Kliewer, A., Miess-Tanneberg, E., Kostenis, E., Schulz, S., Hoffmann, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795447/
https://www.ncbi.nlm.nih.gov/pubmed/35087057
http://dx.doi.org/10.1038/s41467-022-28152-8

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