Engineering pan–HIV-1 neutralization potency through multispecific antibody avidity

Deep mining of B cell repertoires of HIV-1–infected individuals has resulted in the isolation of dozens of HIV-1 broadly neutralizing antibodies (bNAbs). Yet, it remains uncertain whether any such bNAbs alone are sufficiently broad and potent to deploy therapeutically. Here, we engineered HIV-1 bNAb...

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Detalles Bibliográficos
Autores principales: Rujas, Edurne, Cui, Hong, Burnie, Jonathan, Aschner, Clare Burn, Zhao, Tiantian, Insausti, Sara, Muthuraman, Krithika, Semesi, Anthony, Ophel, Jasper, Nieva, Jose L., Seaman, Michael S., Guzzo, Christina, Treanor, Bebhinn, Julien, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795538/
https://www.ncbi.nlm.nih.gov/pubmed/35064083
http://dx.doi.org/10.1073/pnas.2112887119

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