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Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs
The glycosylation of cell surface receptors has been shown to regulate each step of signal transduction, including receptor trafficking to the cell surface, ligand binding, dimerization, phosphorylation, and endocytosis. In this review we focus on the role of glycosyltransferases that are involved i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795723/ https://www.ncbi.nlm.nih.gov/pubmed/35089466 http://dx.doi.org/10.1007/s10719-022-10041-3 |
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author | Takahashi, Motoko Hasegawa, Yoshihiro Maeda, Kento Kitano, Masato Taniguchi, Naoyuki |
author_facet | Takahashi, Motoko Hasegawa, Yoshihiro Maeda, Kento Kitano, Masato Taniguchi, Naoyuki |
author_sort | Takahashi, Motoko |
collection | PubMed |
description | The glycosylation of cell surface receptors has been shown to regulate each step of signal transduction, including receptor trafficking to the cell surface, ligand binding, dimerization, phosphorylation, and endocytosis. In this review we focus on the role of glycosyltransferases that are involved in the modification of N-glycans, such as the effect of branching and elongation in signaling by various cell surface receptors. In addition, the role of those enzymes in the EMT/MET programs, as related to differentiation and cancer development, progress and therapy resistance is discussed. |
format | Online Article Text |
id | pubmed-8795723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-87957232022-01-28 Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs Takahashi, Motoko Hasegawa, Yoshihiro Maeda, Kento Kitano, Masato Taniguchi, Naoyuki Glycoconj J Mini Review The glycosylation of cell surface receptors has been shown to regulate each step of signal transduction, including receptor trafficking to the cell surface, ligand binding, dimerization, phosphorylation, and endocytosis. In this review we focus on the role of glycosyltransferases that are involved in the modification of N-glycans, such as the effect of branching and elongation in signaling by various cell surface receptors. In addition, the role of those enzymes in the EMT/MET programs, as related to differentiation and cancer development, progress and therapy resistance is discussed. Springer US 2022-01-28 2022 /pmc/articles/PMC8795723/ /pubmed/35089466 http://dx.doi.org/10.1007/s10719-022-10041-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Mini Review Takahashi, Motoko Hasegawa, Yoshihiro Maeda, Kento Kitano, Masato Taniguchi, Naoyuki Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs |
title | Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs |
title_full | Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs |
title_fullStr | Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs |
title_full_unstemmed | Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs |
title_short | Role of glycosyltransferases in carcinogenesis; growth factor signaling and EMT/MET programs |
title_sort | role of glycosyltransferases in carcinogenesis; growth factor signaling and emt/met programs |
topic | Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795723/ https://www.ncbi.nlm.nih.gov/pubmed/35089466 http://dx.doi.org/10.1007/s10719-022-10041-3 |
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