Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins

Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for lim...

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Detalles Bibliográficos
Autores principales: Kim, Na-Eun, Song, Yoon-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Microbiological Society of Korea 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795727/
https://www.ncbi.nlm.nih.gov/pubmed/35089584
http://dx.doi.org/10.1007/s12275-022-1502-8
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author Kim, Na-Eun
Song, Yoon-Jae
author_facet Kim, Na-Eun
Song, Yoon-Jae
author_sort Kim, Na-Eun
collection PubMed
description Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms.
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spelling pubmed-87957272022-01-28 Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins Kim, Na-Eun Song, Yoon-Jae J Microbiol Review Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms. The Microbiological Society of Korea 2022-01-28 2022 /pmc/articles/PMC8795727/ /pubmed/35089584 http://dx.doi.org/10.1007/s12275-022-1502-8 Text en © The Microbiological Society of Korea 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Kim, Na-Eun
Song, Yoon-Jae
Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
title Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
title_full Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
title_fullStr Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
title_full_unstemmed Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
title_short Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins
title_sort coordinated regulation of interferon and inflammasome signaling pathways by sars-cov-2 proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795727/
https://www.ncbi.nlm.nih.gov/pubmed/35089584
http://dx.doi.org/10.1007/s12275-022-1502-8
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