Cargando…
Proguanil synergistically sensitizes ovarian cancer cells to olaparib by increasing DNA damage and inducing apoptosis
Ovarian cancer is the second leading cause of cancer-related deaths in women, with low five-year survival rates. Therefore, it is essential to seek new treatment options. Olaparib, a PARP inhibitor, has benefited many ovarian cancer patients, but olaparib is much less effective as a single agent in...
Autores principales: | Wu, Yan, Wu, Tianyu, Hu, Xin, Xu, Simeng, Xiao, Di, Wu, Jingtao, Yan, Xinjian, Yang, Xiaoping, Li, Gaofeng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795793/ https://www.ncbi.nlm.nih.gov/pubmed/35165509 http://dx.doi.org/10.7150/ijms.67027 |
Ejemplares similares
-
Inhibition of PKM2 Enhances Sensitivity of Olaparib to Ovarian Cancer Cells and Induces DNA Damage
por: Zhou, Sichun, et al.
Publicado: (2022) -
Synergistic augmentation of osimertinib‐induced autophagic death by proguanil or rapamycin in bladder cancer
por: Xiao, Di, et al.
Publicado: (2023) -
Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria
por: Wu, Tianyu, et al.
Publicado: (2021) -
Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy
por: Xiao, Di, et al.
Publicado: (2022) -
Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
por: Zhang, Chu-di, et al.
Publicado: (2023)