A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?

Antimicrobial defense is an essential component of host-microbial homeostasis and contributes substantially to oral health maintenance. Dental mesenchymal stromal cells (MSCs) possess multilineage differentiation potential, immunomodulatory properties and play an important role in various processes...

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Detalles Bibliográficos
Autores principales: Andrukhov, Oleh, Blufstein, Alice, Behm, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oral Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795861/
https://www.ncbi.nlm.nih.gov/pubmed/35098213
http://dx.doi.org/10.3389/froh.2021.832976
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author Andrukhov, Oleh
Blufstein, Alice
Behm, Christian
author_facet Andrukhov, Oleh
Blufstein, Alice
Behm, Christian
author_sort Andrukhov, Oleh
collection PubMed
description Antimicrobial defense is an essential component of host-microbial homeostasis and contributes substantially to oral health maintenance. Dental mesenchymal stromal cells (MSCs) possess multilineage differentiation potential, immunomodulatory properties and play an important role in various processes like regeneration and disease progression. Recent studies show that dental MSCs might also be involved in antibacterial defense. This occurs by producing antimicrobial peptides or attracting professional phagocytic immune cells and modulating their activity. The production of antimicrobial peptides and immunomodulatory abilities of dental MSCs are enhanced by an inflammatory environment and influenced by vitamin D(3.) Antimicrobial peptides also have anti-inflammatory effects in dental MSCs and improve their differentiation potential. Augmentation of antibacterial efficiency of dental MSCs could broaden their clinical application in dentistry.
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spelling pubmed-87958612022-01-29 A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential? Andrukhov, Oleh Blufstein, Alice Behm, Christian Front Oral Health Oral Health Antimicrobial defense is an essential component of host-microbial homeostasis and contributes substantially to oral health maintenance. Dental mesenchymal stromal cells (MSCs) possess multilineage differentiation potential, immunomodulatory properties and play an important role in various processes like regeneration and disease progression. Recent studies show that dental MSCs might also be involved in antibacterial defense. This occurs by producing antimicrobial peptides or attracting professional phagocytic immune cells and modulating their activity. The production of antimicrobial peptides and immunomodulatory abilities of dental MSCs are enhanced by an inflammatory environment and influenced by vitamin D(3.) Antimicrobial peptides also have anti-inflammatory effects in dental MSCs and improve their differentiation potential. Augmentation of antibacterial efficiency of dental MSCs could broaden their clinical application in dentistry. Frontiers Media S.A. 2022-01-14 /pmc/articles/PMC8795861/ /pubmed/35098213 http://dx.doi.org/10.3389/froh.2021.832976 Text en Copyright © 2022 Andrukhov, Blufstein and Behm. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oral Health
Andrukhov, Oleh
Blufstein, Alice
Behm, Christian
A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?
title A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?
title_full A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?
title_fullStr A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?
title_full_unstemmed A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?
title_short A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?
title_sort review of antimicrobial activity of dental mesenchymal stromal cells: is there any potential?
topic Oral Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795861/
https://www.ncbi.nlm.nih.gov/pubmed/35098213
http://dx.doi.org/10.3389/froh.2021.832976
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