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Development of I(KATP) Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant K(IR)6.2 Based Channels for Treating DEND Syndrome

Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the K(IR)6.2 subunit of the I(KATP) potassium channel, stand at the basis of most forms of DEND sy...

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Detalles Bibliográficos
Autores principales:	Houtman, Marien J. C., Friesacher, Theres, Chen, Xingyu, Zangerl-Plessl, Eva-Maria, van der Heyden, Marcel A. G., Stary-Weinzinger, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795863/ https://www.ncbi.nlm.nih.gov/pubmed/35095528 http://dx.doi.org/10.3389/fphar.2021.814066

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