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Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview

All living tissues and organs have their respective sizes, critical to various biological functions, such as development, growth, and homeostasis. As tissues and organs generally converge to a certain size, intrinsic regulatory mechanisms may be involved in the maintenance of size regulation. In rec...

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Autor principal: Hirashima, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795865/
https://www.ncbi.nlm.nih.gov/pubmed/35096843
http://dx.doi.org/10.3389/fcell.2021.820391
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author Hirashima, Tsuyoshi
author_facet Hirashima, Tsuyoshi
author_sort Hirashima, Tsuyoshi
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description All living tissues and organs have their respective sizes, critical to various biological functions, such as development, growth, and homeostasis. As tissues and organs generally converge to a certain size, intrinsic regulatory mechanisms may be involved in the maintenance of size regulation. In recent years, important findings regarding size regulation have been obtained from diverse disciplines at the molecular and cellular levels. Here, I briefly review the size regulation of biological tissues from the perspective of control systems. This minireview focuses on how feedback systems engage in tissue size maintenance through the mechanical interactions of constituent cell collectives through intracellular signaling. I introduce a general framework of a feedback control system for tissue size regulation, followed by two examples: maintenance of epithelial tissue volume and epithelial tube diameter. The examples deliver the idea of how cellular mechano-response works for maintaining tissue size.
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spelling pubmed-87958652022-01-29 Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview Hirashima, Tsuyoshi Front Cell Dev Biol Cell and Developmental Biology All living tissues and organs have their respective sizes, critical to various biological functions, such as development, growth, and homeostasis. As tissues and organs generally converge to a certain size, intrinsic regulatory mechanisms may be involved in the maintenance of size regulation. In recent years, important findings regarding size regulation have been obtained from diverse disciplines at the molecular and cellular levels. Here, I briefly review the size regulation of biological tissues from the perspective of control systems. This minireview focuses on how feedback systems engage in tissue size maintenance through the mechanical interactions of constituent cell collectives through intracellular signaling. I introduce a general framework of a feedback control system for tissue size regulation, followed by two examples: maintenance of epithelial tissue volume and epithelial tube diameter. The examples deliver the idea of how cellular mechano-response works for maintaining tissue size. Frontiers Media S.A. 2022-01-14 /pmc/articles/PMC8795865/ /pubmed/35096843 http://dx.doi.org/10.3389/fcell.2021.820391 Text en Copyright © 2022 Hirashima. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hirashima, Tsuyoshi
Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview
title Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview
title_full Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview
title_fullStr Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview
title_full_unstemmed Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview
title_short Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview
title_sort mechanical feedback control for multicellular tissue size maintenance: a minireview
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795865/
https://www.ncbi.nlm.nih.gov/pubmed/35096843
http://dx.doi.org/10.3389/fcell.2021.820391
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