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Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation

The ability of cells to sense diverse environmental signals, including nutrient availability and conditions of stress, is critical for both prokaryotes and eukaryotes to mount an appropriate physiological response. While there is a great deal known about the different biochemical pathways that can d...

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Autores principales: Fidalgo da Silva, E., Fong, J., Roye-Azar, A., Nadi, A., Drouillard, C., Pillon, A., Porter, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795880/
https://www.ncbi.nlm.nih.gov/pubmed/35096832
http://dx.doi.org/10.3389/fcell.2021.806521
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author Fidalgo da Silva, E.
Fong, J.
Roye-Azar, A.
Nadi, A.
Drouillard, C.
Pillon, A.
Porter, L. A.
author_facet Fidalgo da Silva, E.
Fong, J.
Roye-Azar, A.
Nadi, A.
Drouillard, C.
Pillon, A.
Porter, L. A.
author_sort Fidalgo da Silva, E.
collection PubMed
description The ability of cells to sense diverse environmental signals, including nutrient availability and conditions of stress, is critical for both prokaryotes and eukaryotes to mount an appropriate physiological response. While there is a great deal known about the different biochemical pathways that can detect and relay information from the environment, how these signals are integrated to control progression through the cell cycle is still an expanding area of research. Over the past three decades the proteins Tuberin, Hamartin and TBC1D7 have emerged as a large protein complex called the Tuberous Sclerosis Complex. This complex can integrate a wide variety of environmental signals to control a host of cell biology events including protein synthesis, cell cycle, protein transport, cell adhesion, autophagy, and cell growth. Worldwide efforts have revealed many molecular pathways which alter Tuberin post-translationally to convey messages to these important pathways, with most of the focus being on the regulation over protein synthesis. Herein we review the literature supporting that the Tuberous Sclerosis Complex plays a critical role in integrating environmental signals with the core cell cycle machinery.
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spelling pubmed-87958802022-01-29 Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation Fidalgo da Silva, E. Fong, J. Roye-Azar, A. Nadi, A. Drouillard, C. Pillon, A. Porter, L. A. Front Cell Dev Biol Cell and Developmental Biology The ability of cells to sense diverse environmental signals, including nutrient availability and conditions of stress, is critical for both prokaryotes and eukaryotes to mount an appropriate physiological response. While there is a great deal known about the different biochemical pathways that can detect and relay information from the environment, how these signals are integrated to control progression through the cell cycle is still an expanding area of research. Over the past three decades the proteins Tuberin, Hamartin and TBC1D7 have emerged as a large protein complex called the Tuberous Sclerosis Complex. This complex can integrate a wide variety of environmental signals to control a host of cell biology events including protein synthesis, cell cycle, protein transport, cell adhesion, autophagy, and cell growth. Worldwide efforts have revealed many molecular pathways which alter Tuberin post-translationally to convey messages to these important pathways, with most of the focus being on the regulation over protein synthesis. Herein we review the literature supporting that the Tuberous Sclerosis Complex plays a critical role in integrating environmental signals with the core cell cycle machinery. Frontiers Media S.A. 2022-01-14 /pmc/articles/PMC8795880/ /pubmed/35096832 http://dx.doi.org/10.3389/fcell.2021.806521 Text en Copyright © 2022 Fidalgo da Silva, Fong, Roye-Azar, Nadi, Drouillard, Pillon and Porter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Fidalgo da Silva, E.
Fong, J.
Roye-Azar, A.
Nadi, A.
Drouillard, C.
Pillon, A.
Porter, L. A.
Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation
title Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation
title_full Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation
title_fullStr Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation
title_full_unstemmed Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation
title_short Beyond Protein Synthesis; The Multifaceted Roles of Tuberin in Cell Cycle Regulation
title_sort beyond protein synthesis; the multifaceted roles of tuberin in cell cycle regulation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795880/
https://www.ncbi.nlm.nih.gov/pubmed/35096832
http://dx.doi.org/10.3389/fcell.2021.806521
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