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The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention

Gestational diabetes mellitus (GDM) is a high-risk pregnancy complication that is associated with metabolic disorder phenotypes, such as abnormal blood glucose and obesity. The link between microbiota and diet management contributes to metabolic homeostasis in GDM. Therefore, it is crucial to unders...

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Autores principales: Wu, Na, Zhou, Jingwei, Mo, Heng, Mu, Qing, Su, Huiting, Li, Mei, Yu, Yimeng, Liu, Aiyu, Zhang, Qi, Xu, Jun, Yu, Weidong, Liu, Peng, Liu, Guoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795975/
https://www.ncbi.nlm.nih.gov/pubmed/35096649
http://dx.doi.org/10.3389/fcimb.2021.800865
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author Wu, Na
Zhou, Jingwei
Mo, Heng
Mu, Qing
Su, Huiting
Li, Mei
Yu, Yimeng
Liu, Aiyu
Zhang, Qi
Xu, Jun
Yu, Weidong
Liu, Peng
Liu, Guoli
author_facet Wu, Na
Zhou, Jingwei
Mo, Heng
Mu, Qing
Su, Huiting
Li, Mei
Yu, Yimeng
Liu, Aiyu
Zhang, Qi
Xu, Jun
Yu, Weidong
Liu, Peng
Liu, Guoli
author_sort Wu, Na
collection PubMed
description Gestational diabetes mellitus (GDM) is a high-risk pregnancy complication that is associated with metabolic disorder phenotypes, such as abnormal blood glucose and obesity. The link between microbiota and diet management contributes to metabolic homeostasis in GDM. Therefore, it is crucial to understand the structure of the gut microbiota in GDM and to explore the effect of dietary management on the microbiota structure. In this study, we analyzed the composition of the gut microbiota between 27 GDM and 30 healthy subjects at two time points using Illumina HiSeq 2500 platform. The taxonomy analyses suggested that the overall bacteria clustered by diabetes status, rather than diet intervention. Of particular interest, the phylum Acidobacteria in GDM was significantly increased, and positively correlated with blood glucose levels. Moreover, Partial least-squares discriminant analysis (PLS-DA) revealed that certain genera in the phyla Firmicutes, Bacteroidetes, Proteobacteria, and Lentisphaerae characterized the GDM gut microbiota. Correlation analysis indicated that blood glucose levels and BMI index were correlated with the relative abundance of SCFAS-producing genera. Through the comparison between the GDM and healthy samples with or without diet intervention, we discovered that the role of short-term diet management in GDM processes is associated with the change in the Firmicutes/Bacteroidetes ratio and some specific taxa, rather than an alternative gut microbial pattern. Our study have important implications for understanding the beneficial effects of diet intervention on the specific gut microbiota and thus possibly their metabolism in pregnant women with GDM.
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spelling pubmed-87959752022-01-29 The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention Wu, Na Zhou, Jingwei Mo, Heng Mu, Qing Su, Huiting Li, Mei Yu, Yimeng Liu, Aiyu Zhang, Qi Xu, Jun Yu, Weidong Liu, Peng Liu, Guoli Front Cell Infect Microbiol Cellular and Infection Microbiology Gestational diabetes mellitus (GDM) is a high-risk pregnancy complication that is associated with metabolic disorder phenotypes, such as abnormal blood glucose and obesity. The link between microbiota and diet management contributes to metabolic homeostasis in GDM. Therefore, it is crucial to understand the structure of the gut microbiota in GDM and to explore the effect of dietary management on the microbiota structure. In this study, we analyzed the composition of the gut microbiota between 27 GDM and 30 healthy subjects at two time points using Illumina HiSeq 2500 platform. The taxonomy analyses suggested that the overall bacteria clustered by diabetes status, rather than diet intervention. Of particular interest, the phylum Acidobacteria in GDM was significantly increased, and positively correlated with blood glucose levels. Moreover, Partial least-squares discriminant analysis (PLS-DA) revealed that certain genera in the phyla Firmicutes, Bacteroidetes, Proteobacteria, and Lentisphaerae characterized the GDM gut microbiota. Correlation analysis indicated that blood glucose levels and BMI index were correlated with the relative abundance of SCFAS-producing genera. Through the comparison between the GDM and healthy samples with or without diet intervention, we discovered that the role of short-term diet management in GDM processes is associated with the change in the Firmicutes/Bacteroidetes ratio and some specific taxa, rather than an alternative gut microbial pattern. Our study have important implications for understanding the beneficial effects of diet intervention on the specific gut microbiota and thus possibly their metabolism in pregnant women with GDM. Frontiers Media S.A. 2022-01-14 /pmc/articles/PMC8795975/ /pubmed/35096649 http://dx.doi.org/10.3389/fcimb.2021.800865 Text en Copyright © 2022 Wu, Zhou, Mo, Mu, Su, Li, Yu, Liu, Zhang, Xu, Yu, Liu and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Wu, Na
Zhou, Jingwei
Mo, Heng
Mu, Qing
Su, Huiting
Li, Mei
Yu, Yimeng
Liu, Aiyu
Zhang, Qi
Xu, Jun
Yu, Weidong
Liu, Peng
Liu, Guoli
The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention
title The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention
title_full The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention
title_fullStr The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention
title_full_unstemmed The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention
title_short The Gut Microbial Signature of Gestational Diabetes Mellitus and the Association With Diet Intervention
title_sort gut microbial signature of gestational diabetes mellitus and the association with diet intervention
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795975/
https://www.ncbi.nlm.nih.gov/pubmed/35096649
http://dx.doi.org/10.3389/fcimb.2021.800865
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